CD14 Antikörper (APC)

Produktnummer ABIN238454

Der Maus Monoklonal anti-CD14 Antikörper wird verwendet zum Nachweis von CD14 in Proben von Human und Affe. Er wurde validiert für FACS.

Kurzübersicht für CD14 Antikörper (APC) (ABIN238454)

Target: CD14

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD14 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: MEM-18

Produktdetails anti-CD14 Antikörper (APC)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Non-Human Primates

Aufreinigung: Size-exclusion chromatography

Immunogen: A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Suitable for Flow Cytometry analysis of human blood cells using 10 m l reagent / 100 m l of whole blood or 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative and 0.2 % (w/v) high-grade BSA (protease free) as a stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody in the dark at 2-8 °C. Do Not freeze! Avoid prolonged exposure to light.
Shelf Life: One year from despatch.

Haltbarkeit: 12 months

Details zu CD14

Target: CD14

Andere Bezeichnung: CD14

Hintergrund: CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor, it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipo-polysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipo-polysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein

UniProt: P08571

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades