TNF alpha Antikörper

Produktnummer ABIN2192160

Dieses Anti-TNF alpha-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TNF alpha in WB, FACS, IHC (p), Func und IA. Geeignet für Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für TNF alpha Antikörper (ABIN2192160)

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNF alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func), Immunoassay (IA)

Produktdetails anti-TNF alpha Antikörper

Kreuzreaktivität (Details): Cross reactivity: Rat : Yes

Sterilität: 0.2 μm filtered

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: For immuno histology, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-TNF alpha Antikörper (ABIN2192160)

Koobkokkruad, Kadotani, Hutamekalin, Mizutani, Yoshino: "Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affinity." in: Journal of inflammation (London, England), Vol. 8, Issue 1, pp. 31, (2011) (PubMed).

Details zu TNF alpha

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Andere Bezeichnung: Tumor Necrosis Factor-alpha

Hintergrund: Tumor Necrosis Factor alpha (TNF-alpha) is a cytokine which has diverse immunomodulatory, anti tumor and toxic effects. TNF-alpha has been detected in diverse inflammatory status and appears to be a critical mediator in the lethality of septic shock. Furthermore, TNF-alpha has also been found in inflammatory foci such as synovial effusions in rheumatoid arthritis, systemic circulation in septic shock, parasitemia and rejection of renal transplants. The antibody reacts with both rat and mouse natural and recombinant TNF-alpha and recognizes membrane and receptor bound TNF- alpha. The antibody shows neutralizing activity. Aliases TNF-alpha

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome