Caspase 9 Antikörper (AA 299-318)

Produktnummer ABIN1886865

Dieses Anti-Caspase 9-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Caspase 9 in WB, ELISA und ICC. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Caspase 9 Antikörper (AA 299-318) (ABIN1886865)

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-Caspase 9 Antikörper

Bindungsspezifität: AA 299-318

Kreuzreaktivität (Details): It has no cross response to other members in caspase family.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 299 to 318 of human caspase-9.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Referenzen für anti-Caspase 9 Antikörper (ABIN1886865)

Zhang, Yi, Liu, Zhao, Chen: "Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells." in: Journal of agricultural and food chemistry, Vol. 61, Issue 9, pp. 2188-95, (2013) (PubMed).

Details zu Caspase 9

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Andere Bezeichnung: Caspase-9

Hintergrund: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3.Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.Caspase-9 is also activated by granzyme B and CPP32.Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis.Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD.Caspase-9 is expressed in a variety of human tissues.
Synonyms: Mch6, Apaf-3, Casp-9

Molekulargewicht: 46 kDa

UniProt: P55211

Pathways: MAPK Signalweg, RTK Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Endopeptidase Activity