DIABLO Antikörper (AA 222-237)

Produktnummer ABIN1886858

Der Kaninchen Polyklonal Anti-DIABLO-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, DIABLO in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für DIABLO Antikörper (AA 222-237) (ABIN1886858)

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIABLO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-DIABLO Antikörper

Bindungsspezifität: AA 222-237

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 222 to 237 of murine Smac/DIABLO.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Andere Bezeichnung: Smac

Hintergrund: The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes.A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO.Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway.Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases.Smac/DIABLO is expressed in a variety of human and mouse tissues.
Synonyms: DIABLO, mSmac

Molekulargewicht: 25 kDa

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity