Caspase 8 Antikörper (AA 1-227)

Produktnummer ABIN1885811

Der Kaninchen Polyklonal Anti-Caspase 8-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, Caspase 8 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Caspase 8 Antikörper (AA 1-227) (ABIN1885811)

Target: Caspase 8 (CASP8)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Caspase 8 Antikörper

Bindungsspezifität: AA 1-227

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 227 of Human CASP8

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu Caspase 8

Target: Caspase 8 (CASP8)

Andere Bezeichnung: caspase-8

Hintergrund: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family.Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit.Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits.This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli.The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD.This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.[provided by RefSeq]

Molekulargewicht: 58 kDa

Gen-ID: 841

NCBI Accession: NP_001219, NM_001228

Pathways: Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades