BAD Antikörper (pSer57)

Produktnummer ABIN1881101

Der Kaninchen Polyklonal Anti-BAD-Antikörper wurde für DB validiert. Er ist geeignet, BAD in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für BAD Antikörper (pSer57) (ABIN1881101)

Target: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAD Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: RB39407

Produktdetails anti-BAD Antikörper

Bindungsspezifität: pSer57

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S57 of human BAD.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-BAD Antikörper (ABIN1881101)

Galmiche, Ezzoukhry, François, Louandre, Sabbagh, Nguyen-Khac, Descamps, Trouillet, Godin, Regimbeau, Joly, Barbare, Duverlie, Mazière, Chatelain: "BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma." in: Molecular cancer research : MCR, Vol. 8, Issue 8, pp. 1116-25, (2010) (PubMed).

Yu, Sun, Shen, Gao, Fan, Sun: "Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity." in: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 107, (2010) (PubMed).

Details zu BAD

Target: BAD (BCL2-Associated Agonist of Cell Death (BAD))

Andere Bezeichnung: BAD

Hintergrund: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq].

Molekulargewicht: 18392

NCBI Accession: NP_004313, NP_116784

UniProt: Q92934

Pathways: MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, Apoptose, Fc-epsilon Rezeptor Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events