BAD Antikörper (BCL2-Associated Agonist of Cell Death) (pThr94)

Details for Product anti-BAD Antibody No. ABIN1881097, Anbieter: Anmelden zum Anzeigen
Antigen
  • bad
  • fa01b12
  • wu:fa01b12
  • wu:fa96d04
  • BAD
  • BBC2
  • BCL2L8
  • AI325008
  • Bbc2
  • BCL2-associated agonist of cell death b
  • BCL2 associated agonist of cell death
  • BCL2-associated agonist of cell death
  • badb
  • BAD
  • Bad
Epitop
pThr94
62
58
52
49
48
47
47
34
22
21
19
19
19
19
19
19
18
18
18
18
18
18
18
18
18
18
18
17
17
17
15
14
14
12
11
11
11
10
10
9
8
7
5
5
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Maus
815
473
313
20
19
8
5
4
3
2
2
1
1
1
1
1
Wirt
Kaninchen
1004
48
2
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser BAD Antikörper ist unkonjugiert
68
67
67
62
62
61
6
6
6
6
6
6
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Dot Blot (DB)
558
547
404
374
112
79
45
38
15
13
10
8
6
3
2
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen This mouse BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T94 of mouse BAD.
Klon RB39418
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Plasmids, Primers & others Plasmide, Primers & weitere BAD products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung BAD (BAD Antibody Abstract)
Hintergrund Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Synonyms: Bad, Bbc6, Bcl2 antagonist of cell death, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter
NCBI Accession NP_031548
UniProt Q61337
Pathways MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, Apoptose, Fc-epsilon Rezeptor Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events
Applikations-hinweise DB: 1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Bilder des Herstellers
Dot Blot (DB) image for anti-BCL2-Associated Agonist of Cell Death (BAD) (pThr94) antibody (ABIN1881097) Dot blot analysis of mouse BAD Antibody (Phospho T94) Phospho-specific Pab (ABIN18810...
Produkt verwendet in: Kim, Xin, Moioli, Chung, Lee, Chen, Fu, Koch, Mao: "Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing." in: Tissue engineering. Part A, Vol. 16, Issue 10, pp. 3023-31, 2010 (PubMed).

Frenzel, Labi, Chmelewskij, Ploner, Geley, Fiegl, Tzankov, Villunger: "Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad." in: Blood, Vol. 115, Issue 5, pp. 995-1005, 2010 (PubMed).

Quoyer, Longuet, Broca, Linck, Costes, Varin, Bockaert, Bertrand, Dalle: "GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1989-2002, 2010 (PubMed).

Wu, Wang, Schroer, Choi, Chen, Okada, Woo: "Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice." in: Diabetologia, Vol. 52, Issue 10, pp. 2130-41, 2009 (PubMed).

Polzien, Baljuls, Rennefahrt, Fischer, Schmitz, Zahedi, Sickmann, Metz, Albert, Benz, Hekman, Rapp: "Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation." in: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 28004-20, 2009 (PubMed).

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