Caspase 9 Antikörper (N-Term)

Produktnummer ABIN187521

Der Maus Monoklonal anti-Caspase 9 Antikörper (Klon LAP6-96) (ABIN187521) detektiert spezifisch Caspase 9 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Caspase 9 Antikörper (N-Term) (ABIN187521)

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caspase 9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: LAP6-96

Produktdetails anti-Caspase 9 Antikörper

Bindungsspezifität: N-Term

Sterilität: 0.2 μm filtered

Immunogen: Synthetic peptide corresponding to amino acids 2 to 22 of human caspase-9.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody against human Caspase-9 (cysteine-requiring aspartate protease-9). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Purified by 0.2 µm sterile filtration.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu Caspase 9

Target: Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

Andere Bezeichnung: Caspase-9

Hintergrund: Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes, which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-9 is a member of the CED-3 family and is very similar to caspase-3. Pro-caspase-9 can be activated by either caspase-3 or granzyme B, although they cleave the pro-enzyme to different size subunits. Cleavage by granzyme B produces an active enzyme, which is capable of cleaving PARP. Also, the ability of caspase-3 to activate caspase-9 seems to suggest that caspase-9 is further downstream of caspase-3 and may be involved in later changes in cells observed undergoing apoptosis.

Pathways: MAPK Signalweg, RTK Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Endopeptidase Activity