Caspase 8 Antikörper (N-Term)
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- Target Alle Caspase 8 (CASP8) Antikörper anzeigen
- Caspase 8 (CASP8)
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Caspase 8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sterilität
- 0.2 μm filtered
- Immunogen
- Recombinant human caspase-8.
- Klon
- FLICE-1
- Isotyp
- IgG1
- Top Product
- Discover our top product CASP8 Primärantikörper
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- Applikationshinweise
- Western Blot The optimal dilution for a specific application should be determined by the researcher.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Mouse monoclonal antibody against human Caspase-8 (cysteine-requiring aspartate protease-8). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Antibody was purified by 0.2 µm sterile filtration.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
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- Target
- Caspase 8 (CASP8)
- Andere Bezeichnung
- Caspase-8 (CASP8 Produkte)
- Synonyme
- casp8-A antikoerper, xCaspase-8 antikoerper, casp8 antikoerper, CASP8 antikoerper, CASP-8 antikoerper, FLICE antikoerper, MACH antikoerper, Mch5 antikoerper, ALPS2B antikoerper, CAP4 antikoerper, Casp-8 antikoerper, MCH5 antikoerper, caspase-8 antikoerper, zgc:92075 antikoerper, caspase 8 L homeolog antikoerper, death related ced-3/Nedd2-like protein antikoerper, caspase 8 antikoerper, caspase-8 antikoerper, caspase-8-like antikoerper, caspase 8, apoptosis-related cysteine peptidase antikoerper, casp8.L antikoerper, LOC661095 antikoerper, CASP8 antikoerper, LOC5563818 antikoerper, casp8 antikoerper, LOC100222284 antikoerper, Casp8 antikoerper
- Hintergrund
- Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes, which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains, which are removed to activate the enzyme along with cleavage in the two subunits. These subunits then form the active protease, which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis.
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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