CD11b Antikörper (AA 623-728)

Produktnummer ABIN1724905

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD11b in ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für CD11b Antikörper (AA 623-728) (ABIN1724905)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD11b Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC)

Klon: 3A10H5

Produktdetails anti-CD11b Antikörper

Bindungsspezifität: AA 623-728

Verwendungszweck: ITGAM Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-CD11b Antikörper (ABIN1724905)

Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." in: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).

Details zu CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung: ITGAM

Hintergrund: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 127.1 kDa

Gen-ID: 3684

UniProt: P11215

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation