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MAPK10 Antikörper (AA 28-233)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch MAPK10 in WB, ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN1724701

Kurzübersicht für MAPK10 Antikörper (AA 28-233) (ABIN1724701)

Target

Alle MAPK10 Antikörper anzeigen
MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Reaktivität

  • 67
  • 51
  • 37
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 72
  • 8
  • 3
Maus

Klonalität

  • 64
  • 21
Monoklonal

Konjugat

  • 39
  • 10
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MAPK10 Antikörper ist unkonjugiert

Applikation

  • 52
  • 38
  • 31
  • 13
  • 13
  • 10
  • 9
  • 8
  • 8
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Klon

10E4A4
  • Bindungsspezifität

    • 15
    • 11
    • 8
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 28-233

    Verwendungszweck

    MAPK10 Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Tamma, Kalyanaraman, Pahwa, Dominguez, Modesto: "The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells." in: Journal of leukocyte biology, Vol. 73, Issue 5, pp. 682-8, (2003) (PubMed).

    Kinet, Bernard, Mongellaz, Perreau, Goldman, Taylor: "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes." in: Blood, Vol. 100, Issue 7, pp. 2546-53, (2002) (PubMed).

  • Target

    MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

    Andere Bezeichnung

    MAPK10

    Hintergrund

    MAPK10: mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

    Molekulargewicht

    53 kDa

    NCBI Accession

    NP_002744

    UniProt

    P53779

    Pathways

    MAPK Signalweg, WNT Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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