MAP2K4 Antikörper

Produktnummer ABIN1724655

Dieses Anti-MAP2K4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MAP2K4 in IHC und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für MAP2K4 Antikörper (ABIN1724655)

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAP2K4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Klon: 2D10D8

Produktdetails anti-MAP2K4 Antikörper

Verwendungszweck: MAP2K4 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of MAP2K4 expressed in E. Coli.

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MAP2K4 Antikörper (ABIN1724655)

Kim, Vander Griend, Yang, Benson, Dubauskas, Yoshida, Chekmareva, Ichikawa, Sokoloff, Zhan, Karrison, Lin, Stadler, Ichikawa, Rubin, Rinker-Schaeffer: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, (2001) (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).

Details zu MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Andere Bezeichnung: MAP2K4

Hintergrund: MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.
MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.

Gen-ID: 6416

UniProt: P45985

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling