Caspase 8 Antikörper (pTyr380)

Produktnummer ABIN1532005

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Caspase 8 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.Es wurde in 1 Publikation zitiert.

Kurzübersicht für Caspase 8 Antikörper (pTyr380) (ABIN1532005)

Target: Caspase 8 (CASP8)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Caspase 8 Antikörper

Bindungsspezifität: AA 346-395, pTyr380

Verwendungszweck: Caspase-8 (phospho Tyr380) Antibody

Spezifität: Phospho-Caspase-8 (Y380) Polyclonal Antibody detects endogenous levels of Caspase-8 protein only when phosphorylated at Y380.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380. AA range:346-395

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Referenzen für anti-Caspase 8 Antikörper (ABIN1532005)

Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: "Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis." in: The Journal of biological chemistry, Vol. 288, Issue 46, pp. 33263-71, (2013) (PubMed).

Details zu Caspase 8

Target: Caspase 8 (CASP8)

Andere Bezeichnung: Caspase 8

Hintergrund:

Synonyms: CASP8, MCH5, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

Gene Name: CASP8

Protein Name: Caspase8

Molekulargewicht: 55 kDa

Gen-ID: 841

OMIM: 211980

UniProt: Q14790

Pathways: Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades