TLR4 Antikörper

Produktnummer ABIN1449233

Der Maus Monoklonal Anti-TLR4-Antikörper wurde für FACS und IP validiert. Er ist geeignet, TLR4 in Proben von Maus zu detektieren.

Kurzübersicht für TLR4 Antikörper (ABIN1449233)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon: UT49

Produktdetails anti-TLR4 Antikörper

Spezifität: This antibody reacts with mouse TLR4 but doesn't react with mouse MD-2 on flow cytometry.

Aufreinigung: Protein A agarose

Immunogen: Mouse TLR4-MD-2 transfected Ba/F3 cell

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Andere Bezeichnung: CD284 / TLR4

Hintergrund: Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defenses against bacteria or fungi. TLR4 (Toll-like receptor 4) is a member of TLR family, which is human homologue of Toll protein. It has extracellular LRR and an intracellular signaling domain, which is similar to the type I IL-1 receptor. TLR4 is expressed in subpopulations of cells including myeloid cells, B-cells, monocytes, and endothelial cells. Recent studies have suggested that TLR4 might act as a receptor for LPS (lipopolysaccharide). TLR4 alone is not capable of sensing and signaling the presence of LPS, but another molecule MD-2, which is physically associated with TLR4, is required for LPS recognition through TLR4.Synonyms: Toll-like receptor 4

Gen-ID: 21898

NCBI Accession: NP_067272

UniProt: Q9QUK6

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine