Connexin 43/GJA1 Antikörper (C-Term)

Produktnummer ABIN1440034

Dieser Ziege Polyklonal Antikörper detektiert spezifisch Connexin 43/GJA1 in WB, IF, IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Affe, Rind (Kuh), Kaninchen, Huhn, Schwein, Meerschweinchen, Pferd, Schaf, Hamster, Ziege, Avian, Cat und Esel. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für Connexin 43/GJA1 Antikörper (C-Term) (ABIN1440034)

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reaktivität: Human, Maus, Ratte, Hund, Affe, Rind (Kuh), Kaninchen, Huhn, Schwein, Meerschweinchen, Pferd, Schaf, Hamster, Ziege, Avian, Cat, Esel

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Connexin 43/GJA1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-CX43

Sequenz: VKDRVKGRSD PYHATTGPLS PSKDCGSPKY AYFNGCSSPT APLSPMSPPG YKLVTGDRNN SSCRNYNKQA SEQNWANYSA EQNRMGQAGS TISNSHAQPF DFPDDNQNAK KVAAGHELQP LAIVDQRPSS RASSRASSRP RPDDLEI

Spezifität: Detects endogenous levels of total connexin 43.

Produktmerkmale: Gap junction protein, alpha 1, 43 kDa

Aufreinigung: Epitope affinity purified

Immunogen: Purified recombinant peptide derived from within residues 230 aa to the C-terminus of rat CX43 produced in E. coli.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:2,000, IF:1:50-1:250, IHC-P:1:250-1:800, IHC-F:1:250-1:800

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 4 mg/mL

Buffer: PBS, 20 % glycerol and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody solution should be gently mixed before use.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Referenzen für anti-Connexin 43/GJA1 Antikörper (ABIN1440034)

Martins-Marques, Pinho, Zuzarte, Oliveira, Pereira, Sluijter, Gomes, Girao: "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin." in: Journal of extracellular vesicles, Vol. 5, pp. 32538, (2016) (PubMed).

Martins-Marques, Anjo, Pereira, Manadas, Girão: "Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 11, pp. 3040-55, (2016) (PubMed).

Ribeiro-Rodrigues, Catarino, Marques, Ferreira, Martins-Marques, Pereira, Girão: "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 11, pp. 4629-41, (2015) (PubMed).

Details zu Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Andere Bezeichnung: CX43

Hintergrund:

Goat polyclonal to connexin 43, which is a member of the connexin family. Cx43 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. This protein is the major protein of gap junctions in embryonic development and in the heart that are thought to have a crucial role in the synchronized contraction of the heart.

AVSD3, CX43, DFNB38, gap junction protein, alpha 1, 43 kDa, GJA1, GJAL HSS, HLHS1, ODDD antibody.

Pathways: MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization