Connexin 43/GJA1 Antikörper (N-Term)

Produktnummer ABIN2774853

Produktdetails anti-Connexin 43/GJA1 Antikörper

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio), Schaf, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LYLAHVFYVM RKEEKLNKKE EELKVAQTDG VNVDMHLKQI EIKKFKYGIE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against GJA1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GJA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 382 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Andere Bezeichnung: GJA1 (GJA1 Produkte)

Synonyme: AVSD3 antikoerper, CX43 antikoerper, DFNB38 antikoerper, GJAL antikoerper, HLHS1 antikoerper, HSS antikoerper, ODDD antikoerper, Cx43 antikoerper, AU042049 antikoerper, AW546267 antikoerper, Cnx43 antikoerper, Cx43alpha1 antikoerper, Gja-1 antikoerper, Npm1 antikoerper, connexin43 antikoerper, cx43a1 antikoerper, gja1 antikoerper, zfCx43.3 antikoerper, connexin 43 antikoerper, gja1-A antikoerper, cx43 antikoerper, gjal antikoerper, oddd antikoerper, dfnb38 antikoerper, gap junction protein alpha 1 antikoerper, gap junction protein, alpha 1 antikoerper, connexin 43 antikoerper, gap junction protein alpha 1 L homeolog antikoerper, CONNEXIN 43 protein antikoerper, GJA1 antikoerper, Gja1 antikoerper, cx43 antikoerper, gja1.L antikoerper, gja1 antikoerper, CONNEXIN 43 antikoerper

Hintergrund: Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.
Alias Symbols: HSS, CX43, GJAL, ODDD, AVSD3, HLHS1, DFNB38
Protein Interaction Partner: UBC, STAMBP, EPS15, UBQLN4, PSMD4, PSMD2, S100A1, GJA1, CNST, NEDD4, TJP1, HGS, TSG101, SGSM3, GJA5, MAPK7, MAPK3, CAV1, CSNK1D, SRC, PRKCG, PRKCE, PRKCB, PRKCA, MAPK1, NOV, CSK, GJA3,
Protein Size: 382

Molekulargewicht: 42 kDa

Gen-ID: 2697

NCBI Accession: NM_000165, NP_000156

UniProt: Q53FJ6

Pathways: MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization