Girdin Antikörper (pSer1417) (AbBy Fluor® 488)

Produktnummer ABIN1397448

Dieses Anti-Girdin-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Girdin in WB und FACS. Geeignet für Human.

Kurzübersicht für Girdin Antikörper (pSer1417) (AbBy Fluor® 488) (ABIN1397448)

Target: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Girdin Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-Girdin Antikörper (AbBy Fluor® 488)

Bindungsspezifität: pSer1417

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Girdin around the phosphorylation site of Ser1417

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Girdin

Target: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Andere Bezeichnung: Girdin

Hintergrund:

Synonyms: APE, GIV, GRDN, HkRP1, GIRDIN, KIAA1212, Akt phosphorylation enhancer, Coiled-coil domain-containing protein 88A, G alpha-interacting vesicle-associated protein, Girders of actin filament, Hook-related protein 1, CCDC88A

Background: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

Gen-ID: 55704

UniProt: Q3V6T2