PKM2 Antikörper (pSer37)
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- Target Alle PKM2 Antikörper anzeigen
- PKM2 (Pyruvate Kinase M2 (PKM2))
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Bindungsspezifität
- pSer37
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PKM2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- The antibody detects endogenous level of PKM2 only
- Immunogen
- Peptide sequence around phosphorylation site of pSer37 (I-D-S (p) -P-P) derived from Human PKM2.
- Top Product
- Discover our top product PKM2 Primärantikörper
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- Applikationshinweise
- Western Blot: 1:500-1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Lagerung
- 4 °C/-20 °C
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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." in: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).
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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." in: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).
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- Target
- PKM2 (Pyruvate Kinase M2 (PKM2))
- Andere Bezeichnung
- PKM2 (PKM2 Produkte)
- Synonyme
- CTHBP antikoerper, OIP3 antikoerper, PK3 antikoerper, PKM2 antikoerper, TCB antikoerper, THBP1 antikoerper, AA414905 antikoerper, AL024370 antikoerper, AL024424 antikoerper, Pk-2 antikoerper, Pk-3 antikoerper, Pk3 antikoerper, Pkm2 antikoerper, PKM12 antikoerper, PKM antikoerper, pyruvate kinase M1/2 antikoerper, pyruvate kinase, muscle antikoerper, PKM antikoerper, Pkm antikoerper
- Hintergrund
- Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
- Molekulargewicht
- 60 kDa
- Pathways
- Warburg Effekt
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