CTLA4 Antikörper

Produktnummer ABIN135319

Dieser Hamster Monoklonal Antikörper detektiert spezifisch CTLA4 in FACS, ELISA, IP, BR und CoSt. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für CTLA4 Antikörper (ABIN135319)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Maus

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Blocking Reagent (BR), Co-Stimulation (CoSt)

Klon: 9H10

Produktdetails anti-CTLA4 Antikörper

Verwendungszweck: Hamster Anti-Mouse CD152-LE/AF

Spezifität: Mouse CD152, Mr 33-37 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD152 antibody for use in flow cytometry, ELISA, blocking, and costimulation assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CD152

Hintergrund: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.

Gen-ID: 12477

UniProt: P09793

Pathways: Cancer Immune Checkpoints