CTLA4 Antikörper (AA 50-78)

Produktnummer ABIN654422

Der Kaninchen Polyklonal anti-CTLA4 Antikörper wird verwendet zum Nachweis von CTLA4 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für CTLA4 Antikörper (AA 50-78) (ABIN654422)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB23352

Produktdetails anti-CTLA4 Antikörper

Bindungsspezifität: AA 50-78

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IDDM12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids of human IDDM12.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:2000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: IDDM12

Hintergrund: CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Molekulargewicht: 24656

Gen-ID: 1493

NCBI Accession: NP_001032720, NP_005205

UniProt: P16410

Pathways: Cancer Immune Checkpoints