CD11b Antikörper

Produktnummer ABIN135141

Der Ratte Monoklonal anti-CD11b Antikörper (Klon M1-70) (ABIN135141) detektiert spezifisch CD11b in FACS, IP, IHC (fro), ICC, IHC (p) und BR. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Kaninchen, Pavian und Rhesusaffen.

Kurzübersicht für CD11b Antikörper (ABIN135141)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reaktivität: Human, Maus, Kaninchen, Pavian, Rhesusaffen

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD11b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Blocking Reagent (BR)

Klon: M1-70

Produktdetails anti-CD11b Antikörper

Verwendungszweck: Rat Anti-Mouse CD11b-LE/AF

Spezifität: Mouse/Human/Rhesus/Baboon/Rabbit CD11b, Mr 170 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD11b antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung: CD11b

Hintergrund: CD11b, the integrin M subunit, combines with CD18, the integrin 2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.

Gen-ID: 16409, 3684, 714832

UniProt: P05555

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation