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Bcl-2 Antikörper (B-Cell CLL/lymphoma 2) AA 41-54 (FITC) Primary Antibody

BCL2 Reaktivität: Human FACS, ICC, IHC (fro), IHC (p), IP, WB Wirt: Maus Monoclonal Bcl-2-100 FITC
Pubmed (4 references)
Produktnummer ABIN1302954
$484.24
Zzgl. Versandkosten $45.00
100 tests
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle Bcl-2 (BCL2) Antikörper anzeigen
    Bcl-2 (BCL2)
    Bindungsspezifität
    • 65
    • 38
    • 25
    • 24
    • 24
    • 22
    • 22
    • 21
    • 18
    • 17
    • 16
    • 16
    • 16
    • 16
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 41-54
    Reaktivität
    • 503
    • 202
    • 188
    • 41
    • 38
    • 25
    • 22
    • 21
    • 17
    • 16
    • 10
    • 5
    • 5
    • 1
    • 1
    Human
    Wirt
    • 398
    • 128
    • 7
    • 5
    • 1
    Maus
    Klonalität
    • 396
    • 142
    Monoklonal
    Konjugat
    • 234
    • 41
    • 33
    • 26
    • 25
    • 16
    • 15
    • 12
    • 11
    • 11
    • 11
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Bcl-2 Antikörper ist konjugiert mit FITC
    Applikation
    • 343
    • 215
    • 191
    • 155
    • 130
    • 107
    • 92
    • 84
    • 79
    • 36
    • 33
    • 30
    • 20
    • 8
    • 8
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    The mouse monoclonal antibody Bcl-2/100 recognizes Bcl2, a 26 kDa protooncogen with anti-apoptotic effect, expressed in outer mitochondrial membrane, endoplasmic reticulum and nuclear envelope.
    Keine Kreuzreaktivität
    Maus
    Kreuzreaktivität (Details)
    Human
    Immunogen
    Synthetic peptide corresponding to the amino acids 41-54 of human Bcl2
    Klon
    Bcl-2-100
    Isotyp
    IgG1
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (0.4 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Joubert, Marais, Maritz: "Influence of 2-methoxyestradiol on MCF-7 cells: an improved differential interference contrasting technique and Bcl-2 and Bax protein expression levels." in: Biocell : official journal of the Sociedades Latinoamericanas de Microscopi?a Electronica ... et. al, Vol. 33, Issue 1, pp. 67-70, (2009) (PubMed).

    Gugasyan, Christou, OReilly, Strasser, Gerondakis: "Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA." in: Cell death and differentiation, Vol. 13, Issue 7, pp. 1235-7, (2006) (PubMed).

    Laflamme, Israël-Assayag, Cormier: "Apoptosis of bronchoalveolar lavage lymphocytes in hypersensitivity pneumonitis." in: The European respiratory journal, Vol. 21, Issue 2, pp. 225-31, (2003) (PubMed).

    Soilu-Hänninen, Ekert, Bucci, Syroid, Bartlett, Kilpatrick: "Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 12, pp. 4828-38, (1999) (PubMed).

  • Target
    Bcl-2 (BCL2)
    Andere Bezeichnung
    Bcl2 (BCL2 Produkte)
    Synonyme
    Bcl-2, PPP1R50, bcl-2, AW986256, C430015F12Rik, D630044D05Rik, D830018M01Rik, BCL-2, Bcl2, BCL2, apoptosis regulator, B cell leukemia/lymphoma 2, B-cell CLL/lymphoma 2a, B-cell CLL/lymphoma 2 protein, BCL2, Bcl2, bcl2a, BCL-2
    Hintergrund
    Bcl2 (B cell CLL lymphoma 2) is a proto-oncogen, which can contribute to tumorigenesis by counteracting apoptosis in various cell types. The anti-apoptotic effect of Bcl2 is performed by its interactions with suppressors and agonists of cell death and under physiological conditions it is regulated by proteolytic processing and phosphorylation. Bcl2 expression can be detected mainly in lymphoid tissues and in the basal cells of epithelial tissues. It is also a marker that can help in classification of lymphoproliferative diseases and in prognostics of some epithelial neoplasms.
    Pathways
    MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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