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PRKACA Antikörper (Protein Kinase A, alpha) Catalytic Subunit Primary Antibody

PRKACA Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Schaf IP, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN127012
$513.70
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Available
  • Target Alle PRKACA Antikörper anzeigen
    PRKACA
    Bindungsspezifität
    • 15
    • 11
    • 9
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Catalytic Subunit
    Reaktivität
    • 60
    • 36
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte, Rind (Kuh), Schwein, Schaf
    Wirt
    • 64
    • 10
    • 2
    • 1
    Kaninchen
    Klonalität
    • 66
    • 11
    Polyklonal
    Konjugat
    • 45
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRKACA Antikörper ist unkonjugiert
    Applikation
    • 52
    • 30
    • 20
    • 13
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    Recognizes a 40 kDa PKA on SDS-PAGE immunoblots
    Aufreinigung
    Affinity purified
    Immunogen
    Synthetic peptide surrounding amino acid 11 of the catalytic subunit of PKA alpha isoform.
  • Applikationshinweise
    Western blot: 0.5-4 μg/mL, Jukat cell lysate can be used as a positive control. Immunoprecipitation: 20-30 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
    Vorsichtsmaßnahmen
    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C/-80 °C
    Informationen zur Lagerung
    Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
  • Target
    PRKACA
    Andere Bezeichnung
    PRKACA (PRKACA Produkte)
    Synonyme
    PKACA, Calpha, Cs-PKA, PKCA1, PKA, PKCD, Pkaca, zgc:158799, protein kinase cAMP-activated catalytic subunit alpha, protein kinase, cAMP dependent, catalytic, alpha, cAMP-dependent protein kinase catalytic subunit, protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a, PRKACA, Prkaca, kin-1, prkacaa
    Hintergrund
    Protein kinase A (PKA) also known as cAMP-dependent protein kinase, is a 40 kDa protein kinase that phosphorylates serine or threonine residues in target proteins in response to elevated levels of cAMP. The second messenger cAMP is produced in response to a wide variety of hormones & neurotransmitters and regulates cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters & gene transcription. The principle intracellular target for cAMP is PKA. Inactive PKA exists as a tetrameric protein composed of two regulatory (R) subunits and two catalytic (C) subunits. Activation occurs when two cAMP molecules bind to each R subunit which causes a conformational change that releases the active C subunits. Two major PKA isozymes, type I (PKAI) and type II (PKAII) consist of RI and RII respectively, complexed with C. Three different C subunits (alpha, beta, and gamma) and four different R subunits (RI-alpha, RI-beta, RII-alpha, and RII-beta) have been identified. It has been suggested that the complex structure of PKA may be necessary for it to accomplish such diverse functions.Synonyms: PKA C-alpha, cAMP-dependent protein kinase catalytic subunit alpha
    Gen-ID
    5566
    NCBI Accession
    NP_002721
    UniProt
    P17612
    Pathways
    NF-kappaB Signalweg, Hedgehog Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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