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CD11b Antikörper

Name: CD11b Antikörper
SKU: ABIN118516
Price: 1132.01 EUR
Availability: InStock

ITGAM Reaktivität: Human, Affe FACS, IP, IHC (fro), Func Wirt: Maus Monoclonal ICRF44 unconjugated

Staining of human peripheral blood granulocytes with Mouse anti Human CD11b (ABIN118516). (CD11b Antikörper)

1 image

(1 reference)

Produktnummer ABIN118516

Datenblatt (PDF)

Target Alle CD11b (ITGAM) Antikörper anzeigen

CD11b (ITGAM) (Integrin alpha M (ITGAM))
Reaktivität
286

187

74

31

20

19

17

14

11

10

7

4

4

2

2

1
Human, Affe
Wirt
166

122

106

2

1

1
Maus
Passende Sekundärantikörper
Klonalität
299

95

2
Monoklonal
Konjugat
128

41

32

29

20

10

8

8

7

7

5

5

5

5

5

5

5

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
Dieser CD11b Antikörper ist unkonjugiert
Applikation
300

89

88

83

63

49

39

25

23

21

14

14

13

6

5

5

5

4

4

3

2

2

2

2

2

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Spezifität

This antibody recognizes the CD11b cell surface glycoprotein. Clone ICRF44 has been reported to have various functional effects on monocytes, blocking adhesion and stimulating cytokine and chemokine release.

Keine Kreuzreaktivität

Katze

Kreuzreaktivität (Details)

Species reactivity (tested):Human, Cynomolgus Monkey , Rhesus Monkey, Baboon.

Aufreinigung

Affinity Chromatography on Protein G

Immunogen

Rheumatoid synovial cells and Human monocytes. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the mouse Sp2/0 myeloma cell line.

Klon

ICRF44

Isotyp

IgG1

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Applikationshinweise

Flow Cytometry (use 10 μL of 1:10 - 1:100 diluted antibody to label 10^6 cells or 100 μL whole blood). Immunoprecipitation Immunohistochemistry on frozen sections (1:100 - 1:1000) Recommended positive control tissue: Human tonsil. Not suitable for paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

PBS, 0.09 % Sodium Azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Avoid repeated freezing and thawing.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

Store the reconstituted antibody at 2-8 °C for one month (add 0.09% Sodium Azide) or at -20 °C for longer.
Sotiriou, Orlova, Al-Fakhri, Ihanus, Economopoulou, Isermann, Bdeir, Nawroth, Preissner, Gahmberg, Koschinsky, Chavakis: "Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 3, pp. 559-61, (2006) (PubMed).
Target

CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung

CD11b (ITGAM Produkte)

Hintergrund

CD11b is a 165 kD molecule also know as the alpha-M integrin, MAC-1 and CR3. This molecule is expressed as a heterodimer in association with the beta-2 integrin and is found on monocytes, granulocytes, NK cells and some peripheral blood lymphocytes. ICR44 significantly blocks homotypic PNM aggregation on response to FMLP (3,4).Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor

Gen-ID

3684

NCBI Accession

NP_000623

UniProt

P11215

Pathways

Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation