Collagen IV Antikörper

Produktnummer ABIN1106751

Dieses Anti-Collagen IV-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Collagen IV in IHC (fro) und EIA. Geeignet für Human.

Kurzübersicht für Collagen IV Antikörper (ABIN1106751)

Target: Collagen IV (COL4) (Collagen, Type IV (COL4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Collagen IV Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: MC4-HA

Produktdetails anti-Collagen IV Antikörper

Spezifität: This monoclonal antibody reacts with native human collagen type IV, and with heat- denatured collagen IV form in ELISA and immunoblots. There is no cross-reactivity with human collagen I,II,III and V. It stains exclusively basement membranes on cryostat sections of human tissues such as kidney, liver and heart. The extent of expression of the basement membrane component type IV collagen may be correlated with the degree of differentiation of basement membrane producing neoplasms. Neoplastic cells of invasive carcinomas often lack a continuous basement membrane. In diagnostic histopathology antibodies to type IV collagen may help to distinguish between non-invasive (benign or in situ) and invasive lesions. Furthermore the antibody is important in the differential diagnosis of bullous lesions in dermatopathology. In in vitro studies with endothelial cells and smooth muscle cells the antibody is helpful in detection of production collagen type IV. This antibody reacts also with dog collagen IV on cryostate and paraffin sections.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: PEG6000 precipitation + Sepharose 6B gel filtration

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Reconstitute with 1 mL sterile water and add preservative if preferred.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu Collagen IV

Target: Collagen IV (COL4) (Collagen, Type IV (COL4))

Andere Bezeichnung: Collagen Type IV

Hintergrund: Synonyms: COL4A1

Gen-ID: 1282

NCBI Accession: NP_001836

UniProt: P02462