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Collagen IV Antikörper (AA 1571-1669)

Name: Collagen IV Antikörper (AA 1571-1669)
SKU: ABIN707396
Price: 384.62 EUR
Availability: InStock

COL4 Reaktivität: Human, Maus, Ratte, Schwein ELISA, WB, IHC (fro), IHC (p), FACS, IF (p), IF (cc) Wirt: Kaninchen Polyclonal unconjugated

Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Collagen IV Polyclonal Antibody, Unconjugated (ABIN707396) at 1:200, followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, PE conjugated used at 1:200 dilution for 40 minutes at 37°C.

IHC

Formalin-fixed and paraffin embedded human esophageal cancer labeled with Anti-Collagen IV Polyclonal Antibody, Unconjugated (ABIN707396) at 1:200, followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded human esophageal cancer labeled with Anti-Collagen IV Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC (p)

Downregulation of miR-27a with a miR-27a inhibitor prevented high glucose (HG)-induced mesangial cell (MC) proliferation and the expression of ECM-associated profibrotic genes via upregulation of PPARγ expression.

Inhibition of miR-27a with antagomir-27a reduces the expression of profibrotic genes and ECM proteins in the kidney glomeruli of STZ-induced diabetic rats.

IHC (p)

5 Abbildungen

(2 Referenzen)

Produktnummer ABIN707396

Datenblatt (PDF)

Target Alle Collagen IV (COL4) Antikörper anzeigen

Collagen IV (COL4) (Collagen, Type IV (COL4))
Bindungsspezifität
16

15

1

1

1

1

1

1

1

1

1

1
AA 1571-1669
Reaktivität
90

42

40

22

16

11

5

2
Human, Maus, Ratte, Schwein
Wirt
59

27

13
Kaninchen
Passende Sekundärantikörper
Klonalität
71

28
Polyklonal
Konjugat
49

10

7

6

3

2

2

2

2

2

2

2

2

2

2

2

1

1
Dieser Collagen IV Antikörper ist unkonjugiert
Applikation
61

49

30

28

27

26

25

25

20

10

9

8

7

3

2

2

1

1

1

1
ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität

Human, Maus, Schwein, Ratte

Homologie

Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain

Isotyp

IgG

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COL4 Reaktivität: Human ELISA Wirt: Ziege Polyclonal Biotin

Applikationshinweise

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Sato, Coburn: "Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells." in: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005830, (2017) (PubMed).

Wu, Zhang, Ma, Zhang, Qin: "The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats." in: Molecular biology reports, Vol. 39, Issue 9, pp. 9085-93, (2012) (PubMed).
Target

Collagen IV (COL4) (Collagen, Type IV (COL4))

Andere Bezeichnung

Collagen 4 (COL4 Produkte)

Synonyme

collagen, type IV antikoerper, Let-2 antikoerper

Hintergrund

Synonyms: ICH, HANAC, POREN1, arresten, Collagen alpha-1(IV) chain, COL4A1
Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Gen-ID

1282

UniProt

P02462