Collagen IV Antikörper

Produktnummer ABIN135052

Dieser Ziege Polyklonal Antikörper detektiert spezifisch Collagen IV in WB, ELISA, IHC (fro), IHC (p), FACS, IP, ICC und IEM. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Schwein, Kaninchen, Huhn, Chinchilla chinchilla, Hund, Meerschweinchen, Pferd, Japanese macaque (Macaca fuscata), Schaf und Tree shrew. Es wurde in 21+ Publikationen zitiert.

Kurzübersicht für Collagen IV Antikörper (ABIN135052)

Target: Collagen IV (COL4) (Collagen, Type IV (COL4))

Reaktivität: Human, Maus, Ratte, Schwein, Kaninchen, Huhn, Chinchilla chinchilla, Hund, Meerschweinchen, Pferd, Japanese macaque (Macaca fuscata), Schaf, Tree shrew

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Collagen IV Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM)

Produktdetails anti-Collagen IV Antikörper

Verwendungszweck: Goat Anti-Type IV Collagen-UNLB

Spezifität: Reacts with conformational determinants on type IV collagen Referenced species reactivities include - Human 1,12,14,27,29,31,34,36 Chicken 5,13,15 Porcine 11,22,25 Mouse 4,5,7,8,30,32 Chinchilla 17 Rabbit 5,6,14,20,23 Rat 2,3,10,26,27,33,35 Equine 18,28 Sheep 24 Bovine 5,24 Guinea Pig 14 Tree Shrew 21 Canine 9,19 Japanese Macaque 16

Kreuzreaktivität (Details): Exhibits < 10 % cross reactivity with collagen type II, III, IV, V and VI. The antibody has not been tested for reactivity with other ECM proteins (e.g., laminin, fibronectin).

Produktmerkmale: Purified Anti-Type IV Collagen antibody for use in ELISA, immunohistochemistry / immunocytochemistry, electron microscopy, flow cytometry, western blotting, and immunoprecipitation assays.

Aufreinigung: Purified by affinity chromatography on type IV collagen covalently linked to agarose, cross-adsorbed against Collagen types I, II, III, V, and VI for minimal reactivity

Immunogen: Type IV collagen

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Pooled antisera from goats hyperimmunized with type IV collagen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: Borate buffered saline, pH 8.2

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Referenzen für anti-Collagen IV Antikörper (ABIN135052)

Tonello, Lee, Berta: "Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice." in: The journal of pain : official journal of the American Pain Society, Vol. 20, Issue 5, pp. 515-527, (2020) (PubMed).

Zaitoun, Cikla, Zafer, Udho, Almomani, Suscha, Cengiz, Sorenson, Sheibani: "Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy." in: Scientific reports, Vol. 8, Issue 1, pp. 9166, (2019) (PubMed).

Singh, Houng, Reed: "Matrix Metalloproteinase-9 Mediates the Deleterious Effects of α2-Antiplasmin on Blood-Brain Barrier Breakdown and Ischemic Brain Injury in Experimental Stroke." in: Neuroscience, Vol. 376, pp. 40-47, (2019) (PubMed).

Fisslthaler, Zippel, Abdel Malik, Delgado Lagos, Zukunft, Thoele, Siuda, Soehnlein, Wittig, Heidler, Weigert, Fleming: "Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis." in: International journal of molecular sciences, Vol. 20, Issue 12, (2019) (PubMed).

Dias, Kim, Holl, Werne Solnestam, Lundeberg, Carlén, Göritz, Frisén: "Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury." in: Cell, Vol. 173, Issue 1, pp. 153-165.e22, (2019) (PubMed).

Ellenbroek, de Haan, van Klarenbosch, Brans, van de Weg, Smeets, de Jong, Arslan, Timmers, Goumans, Hoefer, Doevendans, Pasterkamp, Meyaard, de Jager: "Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice." in: Scientific reports, Vol. 7, Issue 1, pp. 18039, (2019) (PubMed).

Hu, Dziumbla, Lin, Bibli, Zukunft, de Mos, Awwad, Frömel, Jungmann, Devraj, Cheng, Wang, Fauser, Eberhart, Sodhi, Hammock, Liebner, Müller, Glaubitz, Hammes, Popp, Fleming: "Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy." in: Nature, Vol. 552, Issue 7684, pp. 248-252, (2018) (PubMed).

Mao, Kiss, Ou, Gould: "Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse." in: Disease models & mechanisms, Vol. 10, Issue 4, pp. 475-485, (2017) (PubMed).

Friedrich, Bederson, Sehba: "Gender influences the initial impact of subarachnoid hemorrhage: an experimental investigation." in: PLoS ONE, Vol. 8, Issue 11, pp. e80101, (2015) (PubMed).

Chen, Advani, Thai, Kabir, Sood, Gibson, Yuen, Connelly, Marsden, Kelly, Gilbert, Advani: "SDF-1/CXCR4 Signaling Preserves Microvascular Integrity and Renal Function in Chronic Kidney Disease." in: PLoS ONE, Vol. 9, Issue 3, pp. e92227, (2014) (PubMed).

Mao-Ying, Kavelaars, Krukowski, Huo, Zhou, Price, Cleeland, Heijnen: "The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model." in: PLoS ONE, Vol. 9, Issue 6, pp. e100701, (2014) (PubMed).

Wu, Davis, McMillen, Schaeffer, Zhou, Qi, Mazandarani, Alialy, Hudkins, Lusis, LeBoeuf: "Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation." in: Physiological reports, Vol. 2, Issue 11, (2014) (PubMed).

Abrahamson, St John, Stroganova, Zelenchuk, Steenhard: "Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 61, Issue 10, pp. 706-18, (2013) (PubMed).

Maggi, Ericson, Mascarelli, Bradley, Breitschwerdt: "Bartonella henselae bacteremia in a mother and son potentially associated with tick exposure." in: Parasites & vectors, Vol. 6, pp. 101, (2013) (PubMed).

Mirmalek-Sani, Orlando, McQuilling, Pareta, Mack, Salvatori, Farney, Stratta, Atala, Opara, Soker: "Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering." in: Biomaterials, Vol. 34, Issue 22, pp. 5488-95, (2013) (PubMed).

Manigrasso, Sawyer, Hutchens, Flynn, Maric-Bilkan: "Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats." in: American journal of physiology. Renal physiology, (2012) (PubMed).

Manigrasso, Sawyer, Marbury, Flynn, Maric: "Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induced diabetic rats." in: American journal of physiology. Renal physiology, Vol. 301, Issue 3, pp. F634-40, (2011) (PubMed).

Boyette-Davis, Cata, Zhang, Driver, Wendelschafer-Crabb, Kennedy, Dougherty: "Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients." in: The journal of pain : official journal of the American Pain Society, Vol. 12, Issue 9, pp. 1017-24, (2011) (PubMed).

Liu, Chen, Huang, Chung, Zhou, Fu, Szalai, Lan: "C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes." in: Diabetologia, Vol. 54, Issue 10, pp. 2713-23, (2011) (PubMed).

Glorieux, Bachert, Favoreel, Vandekerckhove, Steukers, Rekecki, Van den Broeck, Goossens, Croubels, Clayton, Nauwynck: "Herpes simplex virus type 1 penetrates the basement membrane in human nasal respiratory mucosa." in: PLoS ONE, Vol. 6, Issue 7, pp. e22160, (2011) (PubMed).

Details zu Collagen IV

Target: Collagen IV (COL4) (Collagen, Type IV (COL4))

Andere Bezeichnung: TypeIV Collagen

Hintergrund:

Description: Goat Anti-Type IV Collagen-UNLB

NCBI_Official_Symbol: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6

Synoynms: COL4

Gen-ID: 1282, 1284, 1285

UniProt: P02462