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CD11b Antikörper

Name: CD11b Antikörper
Brand: antibodies-online
SKU: ABIN1027692
Price: 307.24 EUR
Availability: InStock

ITGAM Reaktivität: Human, Non-Human Primate FACS, IP, IHC (fro), ICC Wirt: Maus Monoclonal ICRF44 unconjugated

Flow cytometry surface staining pattern of human peripheral blood stained using anti-human CD11b (ICRF44) purified antibody (concentration in sample 6 μg/mL) GAM APC. (CD11b Antikörper)

FACS

Separation of human neutrophil granulocytes (red-filled) from CD11b negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD11b (ICRF44) purified antibody (concentration in sample 6 μg/mL) GAM APC. (CD11b Antikörper)

FACS

2 Abbildungen

(3 Referenzen)

Produktnummer ABIN1027692

Datenblatt (PDF)

Target Alle CD11b (ITGAM) Antikörper anzeigen

CD11b (ITGAM) (Integrin alpha M (ITGAM))
Reaktivität
273

177

74

34

20

19

17

14

10

10

7

4

4

2

2

1
Human, Non-Human Primate
Wirt
156

116

105

2

1

1
Maus
Passende Sekundärantikörper
Klonalität
283

94

2
Monoklonal
Konjugat
124

39

33

29

21

10

8

8

7

7

6

6

5

5

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Dieser CD11b Antikörper ist unkonjugiert
Applikation
284

86

86

82

64

48

38

23

23

21

14

14

12

6

5

5

5

4

4

3

2

2

2

2

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Spezifität

The mouse monoclonal antibody ICRF44 recognizes an extracellular epitope of CD11b (Mac-1alpha), a 165-170 kDa type 1 transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells.

Kreuzreaktivität (Details)

Human, Non-Human Primates

Aufreinigung

Purified by protein-A affinity chromatography.

Reinheit

> 95 % (by SDS-PAGE)

Immunogen

Rheumatoid synovial cells and human monocytes.

Klon

ICRF44

Isotyp

IgG1

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Applikationshinweise

Flow cytometry: Recommended dilution: 1-4 μg/mL

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Do not freeze.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Do not freeze.
Tieu, Lee, Sun, Lejeune, Recinos, Ju, Spratt, Guo, Milewicz, Tilton, Brasier: "An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3637-51, (2009) (PubMed).

Masten, Olson, Tarleton, Rund, Schuyler, Mehran, Archibeque, Lipscomb: "Characterization of myeloid and plasmacytoid dendritic cells in human lung." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 11, pp. 7784-93, (2006) (PubMed).

Hua, Sakamoto, Nagaoka: "Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils." in: Journal of leukocyte biology, Vol. 71, Issue 4, pp. 632-40, (2002) (PubMed).
Target

CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung

CD11b (ITGAM Produkte)

Hintergrund

Integrin subunit alpha M,CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18), expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.,Mac-1, Integrin alpha M, ITGAM, CR3A, MO1A, MAC1A

Gen-ID

3684

UniProt

P11215

Pathways

Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation