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CLEC4D encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.
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Human Monoclonal CLEC4D Primary Antibody für CyTOF, FACS - ABIN4900404
Graham, Gupta, Schafer, Reid, Kimberg, Dennehy, Hornsell, Guler, Campanero-Rhodes, Palma, Feizi, Kim, Sobieszczuk, Willment, Brown: The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. in The Journal of biological chemistry 2012
Show all 2 Pubmed References
Human Monoclonal CLEC4D Primary Antibody für FACS - ABIN4897647
Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. in Journal of leukocyte biology 2017
Results show the molecular mechanism of glycolipid recognition through C-type lectin (zeige MBL2 Antikörper) receptors, which may provide clues to rational design for effective adjuvants.
CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule
Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor.
MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficient mice with E. coli-induced sepsis showed lower survival rates and reduced bacterial clearance when compared with control mice, despite similar levels of proinflammatory cytokine production.
activation of CLRs Dectin-2 (zeige CLEC6A Antikörper) and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk (zeige SYK Antikörper)-dependent manner.
The authors report that microbial stimulation triggers Mincle (Clec4e (zeige CLEC4E Antikörper)) expression through the myeloid differentiation primary response gene 88 (MyD88 (zeige MYD88 Antikörper)) pathway; a process that does not require MCL (Clecsf8, Clec4d). Conversely, they show that MCL is constitutively expressed but retained intracellularly until Mincle (zeige CLEC4E Antikörper) is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.
Data show that Mincle (zeige CLEC4E Antikörper), the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production.
MCL regulates the development of vaccine-induced Th17 cells and protective immunity against lethal experimental infection with Blastomyces dermatitidis.
major contributor to activation of innate immunity against M. bovis in experimental model, mirrors Mincle (zeige CLEC4E Antikörper) expression
Clecsf8-/- mice exhibit higher bacterial burdens and increased mortality upon Mycobacterium tuberculosis infection.
These results suggest that MCL positively regulates Mincle (zeige CLEC4E Antikörper) expression through protein-protein interaction via its stalk region, thereby magnifying Mincle (zeige CLEC4E Antikörper)-mediated signaling.
Trehalose 6,6'-dimycolate-induced Mincle (zeige CLEC4E Antikörper) expression is dependent on Dectin-3-mediated NF-kappaB (zeige NFKB1 Antikörper) activation through the CARD9 (zeige CARD9 Antikörper)-BCL10 (zeige BCL10 Antikörper)-MALT1 (zeige MALT1 Antikörper) complex.
Compared to their respective homodimers, Dectin-3 and Dectin-2 (zeige CLEC6A Antikörper) heterodimers bound alpha-mannans more effectively, leading to potent inflammatory responses against fungal infections.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
C-type lectin domain family 4, member D
, C-type lectin domain family 4 member D
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8
, C-type lectin receptor
, C-type lectin superfamily member 8
, C-type lectin-like receptor 6
, macrophage C-type lectin
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8
, C-type lectin, superfamily member 8
, macrophage-restricted C-type lectin