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anti-Human CDK6 Antikörper:
anti-Mouse (Murine) CDK6 Antikörper:
anti-Rat (Rattus) CDK6 Antikörper:
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Human Polyclonal CDK6 Primary Antibody für IF (p), IHC (p) - ABIN670236
Yang, Wang, Hui, Li, Jiang: SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/?-catenin pathway. in Tumour biology 2015
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Human Polyclonal CDK6 Primary Antibody für WB - ABIN3042894
Ren, Huang, Xu, Yang, Yang, Hu: Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells. in Anti-cancer drugs 2015
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Human Monoclonal CDK6 Primary Antibody für ICC, WB - ABIN3043634
Zhou, Lu, Liu, Guo, Liu, Zhou, Yang, Mi, Xu: Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo. in Current cancer drug targets 2015
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Human Monoclonal CDK6 Primary Antibody für IF, IHC (p) - ABIN560298
Quinn, Glassford, Percy, Munson, Marafioti, Rodriguez-Justo, Yong: APRIL promotes cell-cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status. in Blood 2011
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Human Polyclonal CDK6 Primary Antibody für IF, IHC - ABIN349202
Tur, Etschmann, Benz, Leich, Waller, Schuh, Rosenwald, Ertl, Kienitz, Haaf, Bräuninger, Gattenlöhner: The 140-kD isoform of CD56 (NCAM1) directs the molecular pathogenesis of ischemic cardiomyopathy. in The American journal of pathology 2013
Combined PI3Kalpha (zeige PIK3CA Antikörper) and CDK4/6 (zeige CDK4 Antikörper) inhibition significantly improved disease control in human xenograft models compared with either monotherapy.
in ovarian cancer cells, DOT1L (zeige DOT1L Antikörper) regulates the transcription of G1 phase genes CDK6 and CCND3 (zeige CCND3 Antikörper) through H3K79 dimethylation
the MYU/hnRNP-K (zeige HNRNPK Antikörper)/CDK6 pathway functions downstream of Wnt/c (zeige WNT7B Antikörper)-Myc (zeige MYC Antikörper) signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells.
metabolic function of cyclin D3 (zeige CCND3 Antikörper)-CDK6 kinase in cancer cell survival
Describe a regulatory loop miR (zeige MLXIP Antikörper)-218-CDK6/CyclinD1-E2F1 (zeige E2F1 Antikörper) whose disruption may contribute to cell cycle progression in gastric cancer.
Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (zeige E2F1 Antikörper) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (zeige CDK4 Antikörper) inhibitors in breast cancer for the development of more effective combination therapies.
The deletion of CBX3 (zeige CBX3 Antikörper) directly enforces the expression of CDK6 and p21 (zeige CDKN1A Antikörper).
Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.
CDK6-mediated suppression of CD25 (zeige IL2RA Antikörper) is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Antikörper)
CDK6 overexpression is associated with cancer.
PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6 (zeige CDK4 Antikörper)), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 (zeige CDK4 Antikörper) inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.
CDK6-mediated suppression of CD25 (zeige IL2RA Antikörper) is required for initiation of T-ALL by activated Notch1 (zeige NOTCH1 Antikörper). . Pharmacologic inhibition of CDK6 kinase induces CD25 (zeige IL2RA Antikörper) and RUNX1 (zeige RUNX1 Antikörper) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.
Fbxo7 (zeige FBXO7 Antikörper)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (zeige CDKN1B Antikörper) levels. These studies reveal differential cell cycle regulation by Fbxo7 (zeige FBXO7 Antikörper) at different stages in T-cell development.
Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.
Data show that E11/glycoprotein 38 (zeige PDPN Antikörper)(GP38 (zeige PDPN Antikörper)) was up-regulated upon SEMA3A (zeige SEMA3A Antikörper) stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.
Notch3 (zeige NOTCH3 Antikörper) transcription and growth of lymphoma cells was dependent on CDK6.
CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (zeige EGR1 Antikörper) in hematopoietic and leukemic stem cell activation
Cdk4 (zeige CDK4 Antikörper) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 (zeige CDKN2A Antikörper) proteins away from Cdk4 (zeige CDK4 Antikörper).
Cdk6/Ccnd1 (zeige CCND1 Antikörper) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (zeige PGR Antikörper); the chondrocytes then undergo p53 (zeige TP53 Antikörper)-dependent apoptosis
p107 (zeige RBL1 Antikörper) retinoblastoma protein is regulated by Cdk6/Ccnd1 (zeige CCND1 Antikörper) in growth plates.
the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
cyclin-dependent kinase 6
, cell division protein kinase 6-like
, cell division protein kinase 6
, serine/threonine-protein kinase PLSTIRE
, CR2 protein kinase