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anti-Human LLGL1 Antikörper:
anti-Mouse (Murine) LLGL1 Antikörper:
anti-Rat (Rattus) LLGL1 Antikörper:
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Human Monoclonal LLGL1 Primary Antibody für ELISA, WB - ABIN561683
Russ, Louderbough, Zarnescu, Schroeder: Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. in PLoS ONE 2012
Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2 (zeige CNTNAP2 Antikörper)-IgG or LGI1 (zeige LGI1 Antikörper)-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1 (zeige LGI1 Antikörper)-IgG.
Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage.
Our results support the growing appreciation that the tumour regulatory functions of Scribble (zeige SCRIB Antikörper), and other polarity protein family members, are context dependent.
this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy.
Lgl1 (zeige CRISPLD2 Antikörper) has a role in inhibiting glioblastoma
PTEN (zeige PTEN Antikörper) loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C (zeige PRKCZ Antikörper) in glioblastoma cells.
Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo.
inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia (zeige BCL11A Antikörper)
Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control.
Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival
Ablation of Llgl1 gene Results in Severe Brain Malformation.
Lgl1 (zeige Klra7 Antikörper) is required for the development of the olfactory bulb.
results suggest that neural stem cell-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1 (zeige Klra7 Antikörper)-dependent global and cell intrinsic mechanisms.
These results reveal a novel role for Lgl-1 (zeige Klra7 Antikörper) in the regulation of virus-specific T-cell responses and antitumor immunity.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1 (zeige Klra7 Antikörper))-Pax2 (zeige PAX2 Antikörper) protein knockout embryos.
Lgl1 (zeige Klra7 Antikörper) forms two distinct complexes in vivo, Lgl1 (zeige Klra7 Antikörper)-NMIIA and Lgl1 (zeige Klra7 Antikörper)-Par6alpha (zeige PARD6A Antikörper)-aPKCzeta (zeige PRKCZ Antikörper), and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (zeige Klra7 Antikörper).
Collectively these findings indicate that Lgl1 (zeige Klra7 Antikörper) regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.
This is the first study to demonstrate the involvement of Dlg1 (zeige DLG1 Antikörper), Scrib (zeige SCRIB Antikörper), and Lgl1 (zeige Klra7 Antikörper) in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.
Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
mgl-1 mRNA is developmentally expressed in CNS, craniofacial region, eyes, limbs, and the gut (zeige GUSB Antikörper)
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
disks large homolog 4
, lethal(2) giant larvae protein homolog 1
, human homolog to the D-lgl gene protein