anti-HFE (HFE) Antikörper

anti-Hemochromatosis Antikörper (HFE)
Auf finden Sie aktuell 78 Hemochromatosis (HFE) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HFE Proteine (15) und HFE Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 101 HFE Produkte verfügbar.

Meistgesuchte Reaktivitäten zu anti-HFE (HFE) Antikörper

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anti-Human HFE Antikörper:

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Am meisten referenzierte anti-HFE Antikörper

  1. Human Monoclonal HFE Primary Antibody für IF, WB - ABIN395159 : Lehmann, Schuur, Warden, Hammond, Belbin, Kölsch, Lehmann, Wilcock, Brown, Kehoe, Morris, Barker, Coto, Alvarez, Deloukas, Mateo, Gwilliam, Combarros, Arias-Vásquez, Aulchenko, Ikram, Breteler, van Duijn, Oulhaj, Heun, Cortina-Borja, Morgan, Robson, Smith: Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project. in Neurobiology of aging 2011 (PubMed)
    Zeige alle 5 Referenzen für 395159

  2. Human Monoclonal HFE Primary Antibody für ICC, ELISA - ABIN969192 : Hosgood, Menashe, He, Chanock, Lan: PTEN identified as important risk factor of chronic obstructive pulmonary disease. in Respiratory medicine 2009 (PubMed)
    Zeige alle 2 Referenzen für 969192

  3. Human Polyclonal HFE Primary Antibody für IHC (p), WB - ABIN390457 : Valenti, Girelli, Valenti, Castagna, Como, Campostrini, Rametta, Dongiovanni, Messa, Fargion: HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients. in Clinical journal of the American Society of Nephrology : CJASN 2009 (PubMed)
    Zeige alle 2 Referenzen für 390457

  4. Human Polyclonal HFE Primary Antibody für EIA, WB - ABIN453091 : Won, Jeong, Chung, Lee, Hwang, Kim, Lee, Kim, Park, Lee, Kim: Hepatic iron, serum ferritin, HFE mutation, and hepatic fibrosis in chronic hepatitis C. in Intervirology 2009 (PubMed)
    Zeige alle 2 Referenzen für 453091

  5. Human Polyclonal HFE Primary Antibody für IF (p), IHC (p) - ABIN1714561 : Rychtarcikova, Lettlova, Tomkova, Korenkova, Langerova, Simonova, Zjablovskaja, Alberich-Jorda, Neuzil, Truksa: Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. in Oncotarget 2016 (PubMed)

  6. Human Monoclonal HFE Primary Antibody für IF, ELISA - ABIN561252 : Lenarduzzi, Hui, Yue, Ito, Shi, Williams, Bruce, Sakemura-Nakatsugawa, Xu, Schimmer, Liu: Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. in PLoS ONE 2013 (PubMed)

  7. Cow (Bovine) Polyclonal HFE Primary Antibody für IHC, WB - ABIN2781800 : Gleeson, Evans, Bradley, Jones, Peck, Dube, Rigby, Dalton: HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. in The American journal of gastroenterology 2006 (PubMed)

Weitere Antikörper gegen HFE Interaktionspartner

Human Hemochromatosis (HFE) Interaktionspartner

  1. Hjv (zeige HFE2 Antikörper) (--) and Hfe (C282YC282Y) transgenic mice displayed enhanced colonization of deep tissues by Yersinia pseudotuberculosis following oral inoculation, recapitulating enhanced susceptibility of humans with hemochromatosis to disseminated infection with enteropathogenic Yersinia.

  2. Male HFE carriers presented with higher iron concentration, transferrin (zeige Tf Antikörper) saturation, and ferritin (zeige FTL Antikörper) levels than females

  3. No significant differences in frequencies of the alleles with mutations in coding regions of the HFE gene (C282Y, H63D, and S65C) were detected between the analyzed patients (with stomach cancer, metabolic syndrome, fatty liver disease, or type 2 diabetes mellitus) and the control Caucasoid sample

  4. these findings support a larger scale screening for HERPUD1 (zeige HERPUD1 Antikörper) R50H and HFE H63D variants in the sub-group of 1ATD patients developing significant chronic hepatic injuries (hepatomegaly, chronic cholestasis, elevated liver enzymes) and at risk developing liver cirrhosis.

  5. There was a time-dependent improvement in the interpretation of the clinical significance of HFE genotypes. HFE molecular genetic testing, performed by non-US Food and Drug Administration-approved laboratory-developed tests, demonstrated excellent accuracy, sensitivity, and specificity. Clinical interpretations were more heterogeneous, probably owing to the low clinical penetrance of some common HFE genotypes

  6. comparison between the 2 methods by Fleiss' kappa analysis showed that 5' nuclease (zeige DCLRE1C Antikörper) assay identified the H63D and S65C haplotype as well as the reference method in all 153 tested samples. Our results showed that novel method probe-based real-time PCR were capable to detect 2 adjacent polymorphisms without errors in genotyping

  7. We discuss herein the puzzling distribution of the two major hemochromatosis HFE mutations associated with hereditary hemochromatosis. Thus, one can observe a low frequency of C282Y and, in contrast, one of the highest European frequencies of H63D in the Basque population.

  8. The results show an association between presence of one or both H63D alleles and development of BIP (zeige GDF10 Antikörper) in testicular cancer patients treated with bleomycin combination chemotherapy.

  9. C282Y but not H63D mutation of HFE was related to elevated cancer risk.

  10. Rare HFE variants are therefore the most frequent cause of hemochromatosis in non-C282Y homozygote HFE patients

Mouse (Murine) Hemochromatosis (HFE) Interaktionspartner

  1. the aging HFE KO mouse on an SV129 genetic background has the potential to facilitate the investigation of cardiomyopathy induced by HFE gene mutations.

  2. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  3. Single Hjv (zeige HFE2 Antikörper)(-)/(-) and double Hfe(-)/(-)Hjv (zeige HFE2 Antikörper)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (zeige HFE2 Antikörper) regulate hepcidin (zeige HAMP Antikörper) via the same pathway.

  4. Results show that HFE requires HJV (zeige HFE2 Antikörper) to activate downstream signal transduction pathways for hepcidin (zeige HAMP Antikörper) regulation.

  5. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  6. results provide evidence that HFE induces hepcidin (zeige HAMP Antikörper) expression via the BMP pathway: HFE interacts with ALK3 (zeige BMPR1A Antikörper) to stabilize ALK3 (zeige BMPR1A Antikörper) protein and increase ALK3 (zeige BMPR1A Antikörper) expression at the cell surface.

  7. These results support in vivo studies which suggest that Hfe and Tfr2 (zeige TFR2 Antikörper) can independently regulate hepcidin (zeige HAMP Antikörper).

  8. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  9. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  10. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (zeige BIRC5 Antikörper) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

HFE Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Alternative names and synonyms associated with HFE

  • hemochromatosis (HFE) Antikörper
  • hemochromatosis (Hfe) Antikörper
  • HFE1 Antikörper
  • HH Antikörper
  • HLA-H Antikörper
  • MR2 Antikörper
  • MVCD7 Antikörper
  • TFQTL2 Antikörper

Bezeichner auf Proteinebene für anti-Hemochromatosis (HFE) Antikörper

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
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