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anti-Human GRP78 Antikörper:
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Chicken Polyclonal GRP78 Primary Antibody für FACS, ICC - ABIN446401
Pepping, Freeman, Gupta, Keller, Bruce-Keller: NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. in American journal of physiology. Endocrinology and metabolism 2013
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Human Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN152679
Shin, Feltri, Wrabetz: Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
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Human Monoclonal GRP78 Primary Antibody für IHC, ELISA - ABIN969204
Honda, Horie, Daito, Ikuta, Tomonaga: Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. in Journal of virology 2009
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Human Polyclonal GRP78 Primary Antibody für IF (cc), IF (p) - ABIN673554
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
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Human Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN4316288
Sharma, Masri, Jo, Bernath, Martin, Funk, Gera: Protein kinase C regulates internal initiation of translation of the GATA-4 mRNA following vasopressin-induced hypertrophy of cardiac myocytes. in The Journal of biological chemistry 2007
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Cow (Bovine) Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN361825
Luo, Mao, Lee, Lee: GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. in Molecular and cellular biology 2006
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Dog (Canine) Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN863190
Cho, Park, Kim, Kim, Kim, Jang: BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1. in Molecular and cellular biology 2006
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Human Polyclonal GRP78 Primary Antibody für ELISA, WB - ABIN561386
Lindenmeyer, Rastaldi, Ikehata, Neusser, Kretzler, Cohen, Schlöndorff: Proteinuria and hyperglycemia induce endoplasmic reticulum stress. in Journal of the American Society of Nephrology : JASN 2008
Show all 2 Pubmed References
Chicken Polyclonal GRP78 Primary Antibody für FACS, ICC - ABIN446404
Rasche, Menoret, Dubljevic, Menu, Vanderkerken, Lapa, Steinbrunn, Chatterjee, Knop, Düll, Greenwood, Hensel, Rosenwald, Einsele, Brändlein: A GRP78-Directed Monoclonal Antibody Recaptures Response in Refractory Multiple Myeloma with Extramedullary Involvement. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Human Polyclonal GRP78 Primary Antibody für WB - ABIN2801942
Ting, Lee: Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation. in DNA (Mary Ann Liebert, Inc.) 1988
In amphibians, the association of BiP with unfolded protein and its possible role in aggresome function may be vital in the maintenance of cellular proteostasis.
Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.
Cancer-associated fibroblasts induced GRP78 expression in A549 and SPCA-1 (zeige ATP2C1 Antikörper) cells to facilitate Non-Small Cell Lung Cancer cell migration and invasion
results suggest that the cooperative effects of radiotherapy and cetuximab could be further improved by inhibiting GRP78 in non-responsive oropharyngeal carcinoma patients
Study reports that the endoplasmic reticulum luminal co-chaperone ERdj4/DNAJB9 (zeige DNAJB9 Antikörper) is a selective IRE1 (zeige ERN1 Antikörper) repressor that promotes a complex between the luminal Hsp70 (zeige HSP70 Antikörper) BiP (zeige GDF10 Antikörper) and the luminal stress-sensing domain of IRE1alpha (zeige ERN1 Antikörper).
GRP78 role in the resistance to cisplatin in the nasopharyngeal carcinoma cells.
High expression of GRP78 is associated with nonalcoholic steatohepatitis.
Data show that cancer-associated fibroblasts (CAFs (zeige TBX1 Antikörper))-derived hepatocyte growth factor (HGF (zeige HGF Antikörper)) or recombinant HGF (zeige HGF Antikörper) activated c-Met/phosphoinositide 3-kinase (PI3K (zeige PIK3CA Antikörper))/Akt (zeige AKT1 Antikörper) and glucose-regulated protein 78 (GRP78) signalling pathways in ovarian cancer cells.
HSPA5/BIP has roles in endoplasmic reticulum stress, autophagy and apoptosis; inhibitors of HSPA5 could be useful in cancer treatment
Immunohistochemical analysis showed that STAT3 (zeige STAT3 Antikörper), GRP78 and BAX (zeige BAX Antikörper) protein levels in the combination group were significantly higher than those in STAT3 (zeige STAT3 Antikörper) group and CDDP group (P<0.05). Exogenous STAT3 (zeige STAT3 Antikörper) and CDDP may synergistically inhibit the xenograft tumour growth through up-regulation of BAX (zeige BAX Antikörper) protein via GRP78.
GRP78 inhibition enhances ATF4 (zeige ATF4 Antikörper)-induced cell death by the deubiquitination and stabilization of CHOP (zeige DDIT3 Antikörper) in human osteosarcoma cells.
the chaperone 78-kDa glucose-regulated protein (GRP78) protects the MPD (zeige MVD Antikörper) against PDI (zeige PADI1 Antikörper)-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 (zeige ADAM17 Antikörper) inhibition.
This paper reports the localization of both GRP78 and HSP60 (zeige HSPD1 Antikörper) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (zeige HSPD1 Antikörper) in the sperm midpiece.
BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death
Over-expression of GRP78 enhances replication of Porcine Circovirus 2.
These results indicate that GRP78, but not nutritional status, is a potent up-regulator of hepatic PTC (zeige PTCH1 Antikörper)-mRNA levels during induction of ER stress in vivo.
Data suggest that activation of GRP78/Ire1 (zeige ERN1 Antikörper)/Xbp1 (zeige XBP1 Antikörper) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Upregulating HSF1 (zeige HSF1 Antikörper) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (zeige DDIT3 Antikörper) and increasing HSP70 (zeige HSP70 Antikörper) a5 (BiP/GRP78). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (zeige HSF1 Antikörper) being one likely key player in both systems.
These results demonstrate a key role for GRP78 in alveolar epithelial cell survival.
These results indicate that GRP78, an endoplasmic reticulum chaperon of the HSP70 (zeige HSP70 Antikörper) family, is a novel host factor involved at multiple steps of the Japanese encephalitis virus life cycle and could be a potential therapeutic target.
Genetic or pharmacologic inhibition of the HSPA5-GPX4 pathway enhanced gemcitabine sensitivity by disinhibiting ferroptosis in vitro and in both subcutaneous and orthotopic animal models of PDAC.
The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78- and CHOP (zeige DDIT3 Antikörper)-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.
Endoplasmic reticulum stress gene GRP78 is involved in signaling pathway during hepatitis B virus-mediated hepatocarcinogenesis.
data show that Med inhibits ER stress-induced apoptosis and promotes osteoblast cell survival by targeting GRP78.
These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1 (zeige SIL1 Antikörper), in Alzheimer's disease-like tau hyperphosphorylation.
Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
78 kDa glucose-regulated protein
, heat shock 70 kDa protein 5
, Protein 1603
, 78 kDa glucose-regulated protein homolog
, luminal-binding protein
, glucose-regulated protein 78
, glucose-regulated protein 78kDa
, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
, GRP 78
, heavy-chain binding protein BiP
, immunoglobulin heavy chain-binding protein
, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
, glucose-regulated protein, 78kDa
, XAP-1 antigen
, glucose regulated protein, 78 kDa
, heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
, heat shock 70kD protein 5
, heat shock 70kDa protein 5 (glucose-regulated protein)
, steroidogenesis-activator polypeptide