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RAP1 (zeige TERF2IP ELISA Kits)-mediated MEK (zeige MAP2K1 ELISA Kits)/ERK (zeige MAPK1 ELISA Kits) pathway defects in Kabuki syndrome.
These findings provide the first evidence linking Rap1A with ovarian cancer development through the ERK/p38 (zeige MAPK1 ELISA Kits) and Notch (zeige NOTCH1 ELISA Kits) signaling pathways, indicating that Rap1A may be used as a novel diagnostic marker or a therapeutic target for ovarian cancer.
High RAP1 (zeige RABGEF1 ELISA Kits) expression is associated with neuroblastoma (zeige ARHGEF16 ELISA Kits).
Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction
Unlike Rap1B (zeige RAP1B ELISA Kits), phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS (zeige RAP1GDS1 ELISA Kits)-607.
SHANK1 (zeige SHANK1 ELISA Kits) and SHANK3 (zeige SHANK3 ELISA Kits) act as integrin activation inhibitors by sequestering active Rap1 (zeige RABGEF1 ELISA Kits) and R-Ras via the SPN (zeige SPN ELISA Kits) domain and thus limiting their bioavailability at the plasma membrane.
These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.
These data suggested that HBV-infection could up-regulate the expression of miR (zeige MLXIP ELISA Kits)-203a, thus down regulated the expression of Rap1a.
Studies indicate that Rap (zeige LRPAP1 ELISA Kits) interacting proteins decide the subcellular localization of Rap (zeige LRPAP1 ELISA Kits), and the interaction modes with downstream Rap (zeige LRPAP1 ELISA Kits) effectors.
A receptor type-protein tyrosine phosphatase alpha (zeige PTPRA ELISA Kits)-Src (zeige SRC ELISA Kits) family kinase-Rap1 (zeige RABGEF1 ELISA Kits) pathway was identified as responsible for recruiting myosin IIB (zeige MYH10 ELISA Kits) to the zonula adherens in epithelial cells and supporting contractile tension.
Rap1 (zeige TERF2IP ELISA Kits) increases KRIT-1 (zeige KRIT1 ELISA Kits) targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity.
neuronal Rap1 (zeige TERF2IP ELISA Kits) critically regulates leptin (zeige LEP ELISA Kits) sensitivity
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
Results from comparative proteomics identified Rap1 as a novel legionella-containing-vacuole host component implicated in intracellular replication of Legionella pneumophila.
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature
Rap1 deficiency impaired T-cell homeostasis.
Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
RAP1A, member of RAS oncogene family
, ras-related protein Rap-1A
, GTP-binding protein smg p21A
, RAS-related protein RAP1A
, Ras-related protein Krev-1
, RAS-related protein 1a
, ras-related protein Krev-1
, GTP-binding protein smg-p21A
, GTP-binding protein SMG-P21A