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Mutation of the basic clusters in the CD28 (zeige CD28 ELISA Kits) cytoplasmic domain reduced the recruitment to the CD28 (zeige CD28 ELISA Kits)-Lck complex of protein kinase (zeige CDK7 ELISA Kits) Ctheta; (PKCtheta (zeige PRKCQ ELISA Kits);), which serves as a key effector kinase in the CD28 (zeige CD28 ELISA Kits) signaling pathway.
A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice)
this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity
this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development
Aurora A (zeige AURKA ELISA Kits) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (zeige AURKA ELISA Kits) is required for maintaining Lck active during T-cell activation.
essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells
Lck-Dlx5 (zeige DLX5 ELISA Kits) mice develop T-ALLs that consistently acquire overexpression of Myc (zeige MYC ELISA Kits) and activation of Akt (zeige AKT1 ELISA Kits).
Lck-CD8 (zeige CD8A ELISA Kits) interaction is required for initial CD8 (zeige CD8A ELISA Kits) recruitment.
The kinase Itk (zeige ITK ELISA Kits) and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
autophosphorylation of the LCK active-site loop is indispensable for its catalytic activity and LCK can stimulate its own activation by adopting a more open conformation, which can be modulated by point mutations, and CD4 (zeige CD4 ELISA Kits) and CD8 (zeige CD8A ELISA Kits), T-cell coreceptors, can enhance LCK activity
the central biological role of the novel IL-2 (zeige IL2 ELISA Kits)-R/Lck/PLCgamma/PKCtheta (zeige PRKCQ ELISA Kits);/alphaPIX (zeige ARHGEF6 ELISA Kits)/Rac1/PYGM (zeige PYGM ELISA Kits) signalling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation.
Possible models of regulation of Lck by Aurora-A (zeige AURKA ELISA Kits) during T cell activation are described in the review.
Data suggest that T cell activation through the TCR complex is accompanied by the de novo activation of T-lymphocyte specific protein tyrosine kinase p56lck (Lck) and that phosphorylation of Tyr (zeige TYR ELISA Kits)(394) plays a role in Lck function that goes beyond inducing an open conformation of the kinase.
WASH has a pivotal role for regulation of NK cell cytotoxicity through Lck-mediated Y141 tyrosine phosphorylation.
The results have revealed a novel splicing homozygous mutation of LCK that may be responsible for the clinical phenotype of HPV infection from latency to invasive carcinoma.
this study show that Lck as a major signaling hub of CD147 in T cells
data indicate that HSP65 (zeige HSPD1 ELISA Kits) suppresses cholesterol efflux and increases cellular cholesterol content through an Lck-mediated pathway in T cells
LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
lymphocyte protein tyrosine kinase
, lymphocyte-specific protein tyrosine kinase
, tyrosine-protein kinase Lck-like
, leukocyte C-terminal Src kinase
, lymphocyte cell-specific protein-tyrosine kinase
, proto-oncogene tyrosine-protein kinase LCK
, T-lymphocyte specific protein tyrosine kinase p56lck
, p56(LSTRA) protein-tyrosine kinase
, t cell-specific protein-tyrosine kinase
, tyrosine-protein kinase Lck
, tyrosine protein kinase
, tyrosine-protein kinase LCK