Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human GAB2 Antikörper:
anti-Rat (Rattus) GAB2 Antikörper:
anti-Mouse (Murine) GAB2 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal GAB2 Primary Antibody für FACS, WB - ABIN1881358
Yamasaki, Nishida, Hibi, Sakuma, Shiina, Takeuchi, Ohnishi, Hirano, Saito: Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal GAB2 Primary Antibody für ELISA, WB - ABIN253292
Bentires-Alj, Gil, Chan, Wang, Wang, Imanaka, Harris, Richardson, Neel, Gu: A role for the scaffolding adapter GAB2 in breast cancer. in Nature medicine 2006
Human Polyclonal GAB2 Primary Antibody für IF (p), IHC (p) - ABIN681178
Zhan, Xu, Chen, Wang, Yanfeng, Dan, Zhan, Shi: Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. in Synapse (New York, N.Y.) 2014
Human Polyclonal GAB2 Primary Antibody für IHC, IHC (p) - ABIN4313051
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
The model showed agreement at several key nodes, involving scaffolding proteins Gab1 (zeige GAB1 Antikörper), Gab2 and their complexes with Shp2 (zeige PTPN11 Antikörper). VEGFR2 (zeige KDR Antikörper) recruitment of Gab1 (zeige GAB1 Antikörper) is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (zeige KDR Antikörper) complexes more transiently than Gab1 (zeige GAB1 Antikörper), VEGFR2 (zeige KDR Antikörper) complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1 (zeige BAK1 Antikörper), SPRY4 (zeige SPRY4 Antikörper) and GAB2 SNPs in pediatric germ cell tumors(GCT (zeige QPCT Antikörper)); found a variant in SPRY4 (zeige SPRY4 Antikörper) was associated with reduced risk of GCT (zeige QPCT Antikörper); a variant in BAK1 (zeige BAK1 Antikörper) was positively associated with GCT (zeige QPCT Antikörper) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (zeige QPCT Antikörper).
overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1 (zeige CXCL1 Antikörper), CXCL2 (zeige CXCL2 Antikörper) and CXCL8 (zeige IL8 Antikörper) that is IKKbeta (zeige IKBKB Antikörper)-dependent.
GAB2 is a key intermediary between YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) and the PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) pathway.
The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.
ERK1 (zeige MAPK3 Antikörper) and ERK2 (zeige MAPK1 Antikörper) interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 (zeige MAPK1/3 Antikörper) activation.
GAB2 is a functional downstream target of miR (zeige MLXIP Antikörper)-302a in glioma. GAB2 role in cell proliferation, migration and invasion of glioma.
overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells.
GAB2 might promote hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cell proliferation by enhancing ERK (zeige EPHB2 Antikörper) signaling.
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1 (zeige GAB1 Antikörper)/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1 (zeige GAB1 Antikörper)/Gab2 are recruited to Il4r (zeige IL4R Antikörper), synergistically enhancing downstream signal amplification. (Gab1 (zeige GAB1 Antikörper) = growth factor receptor bound protein 2-associated protein 1 (zeige GAB1 Antikörper); Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (zeige IL4R Antikörper) = interleukin-4 receptor (zeige IL4R Antikörper))
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (zeige SLC13A2 Antikörper) gene expression and GCH (zeige GCH1 Antikörper); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Data indicate that fetal liver cells isolated from homozygous STAT5 (zeige STAT5A Antikörper) mutant mice lacking Gab2 showed significant reduction in HSC (zeige FUT1 Antikörper) number and survival.
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97