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the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L (zeige TNFSF9 ELISA Kits) was further investigated.
Egr2 (zeige EGR2 ELISA Kits)-driven cell surface proteins LAG-3 (zeige LAG3 ELISA Kits) and 4-1BB can identify dysfunctional tumor antigen-specific CD8 (zeige CD8A ELISA Kits)(+) TIL (zeige TLR1 ELISA Kits).
Findings indicate that CD137 antigen is a useful marker that can be used for identifying Mycobacterium tuberculosis (Mtb (zeige NCAPG2 ELISA Kits))-reactive CD4 (zeige CD4 ELISA Kits)(+) T cells (Mtb (zeige NCAPG2 ELISA Kits)-reactive CD4 (zeige CD4 ELISA Kits)(+) T cells) by flow cytometry.
Anti-4-1BB single chain variable fragments enhanced surface CD69 (zeige CD69 ELISA Kits) expression and interleukin-2 (zeige IL2 ELISA Kits) production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the selected single chain variable fragments. The data from this study have provided a rationale for further experiments involving the biological functions of anti-4-1BB single chain variable fragments in future studies.
Studies suggest that adoptive T cell therapy and CD137 antigen offer much opportunity to raise the efficacy of current cancer immunotherapies.
Triple costimulation via CD80 (zeige CD80 ELISA Kits), 4-1BB, and CD83 (zeige CD83 ELISA Kits) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2 (zeige IL2 ELISA Kits).
These studies provide the first direct evidence that ligation of tumour necrosis factor (zeige TNF ELISA Kits) superfamily members and their cognate receptors is important for the control of viral lytic replication.
Our findings provide a novel, TNFRSF9-positive, reactive astrocytic phenotype in human gliomas
Human genetic evidence for involvement of CD137 in atherosclerosis
As a result of becoming activated, transferred human T lymphocytes express the inducible surface antigens hPD-1 (zeige PDCD1 ELISA Kits) and hCD137 on their plasma membrane.
Data indicate that anti-CD137 agonists can function as inhibitors of CD137L (zeige TNFSF9 ELISA Kits) signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
These studies reveal that the costimulatory effects of TLR1 (zeige TLR1 ELISA Kits)-TLR2 (zeige TLR2 ELISA Kits) signaling in CD8 (zeige CD8A ELISA Kits)(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response.
This study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica.
Constitutive interaction between 4-1BB and 4-1BBL (zeige TNFSF9 ELISA Kits) on murine LPS (zeige TLR4 ELISA Kits)-activated bone marrow dendritic cells masks detection of 4-1BBL (zeige TNFSF9 ELISA Kits) by TKS (zeige PTK6 ELISA Kits)-1 but not 19H3 antibody.
results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 (zeige CD8A ELISA Kits) T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed
High CD137 expression is associated with neoplasms.
Ly6C, 4-1BB, and KLRG1 (zeige KLRG1 ELISA Kits) have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease
CD137 Regulates NFATc1 (zeige NFATC1 ELISA Kits) Expression in Mouse VSMCs through TRAF6 (zeige TRAF6 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) p65 (zeige NFkBP65 ELISA Kits) Signaling Pathway.
4-1BB triggering preferentially enhances the expansion of CD8 (zeige CD8A ELISA Kits)+ T cells through the amplification of autocrine IL-2 (zeige IL2 ELISA Kits)/IL-2R signaling loop.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
tumor necrosis factor receptor superfamily, member 9
, tumor necrosis factor receptor superfamily member 9
, 4-1BB ligand receptor
, CD137 antigen
, T cell antigen ILA
, T-cell antigen 4-1BB homolog
, T-cell antigen ILA
, homolog of mouse 4-1BB
, induced by lymphocyte activation (ILA)
, interleukin-activated receptor, homolog of mouse Ly63
, receptor protein 4-1BB
, T-cell antigen 4-1BB
, secreted CD137 antigen