Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Mouse (Murine) Antikörper:
anti-Rat (Rattus) Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Chicken Monoclonal SYT2 Primary Antibody für WB - ABIN968922
Geppert, Archer, Südhof: Synaptotagmin II. A novel differentially distributed form of synaptotagmin. in The Journal of biological chemistry 1991
Show all 3 Pubmed References
Human Polyclonal SYT2 Primary Antibody für IP, IHC - ABIN1742202
Johnson, Franz, Kuhn, Furness, Rüttiger, Münkner, Rivolta, Seward, Herschman, Engel, Knipper, Marcotti: Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. in Nature neuroscience 2009
Show all 3 Pubmed References
Human Polyclonal SYT2 Primary Antibody für ELISA, WB - ABIN4357213
Young, Neher: Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. in Neuron 2009
knockdown of synaptotagmin 2 (syt2) reduces synchronous release, whereas knockdown of synaptotagmin 7 (syt7 (zeige SYT7 Antikörper)) reduces the asynchronous component of release.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (zeige CA2 Antikörper)+)-regulated tethers to the Pplasma membrane.
SYT2 mutations cause a novel complex presynaptic congenital myasthenic syndrome characterized by motor neuropathy causing lower limb wasting and foot deformities, reflex potentiation following exercise and a prolonged period of posttetanic potentiation
Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy.
Human SytII is not an effective receptor for Botulinum neurotoxin D-C.
synaptotagmin-II is not a high affinity receptor for BoNT/B (zeige BoNT/B Antikörper) and G due to a phenylalanine to leucine mutation in its luminal domain present only in humans and chimpanzees
role for synaptotagmin II as calcium-sensor during phagocytosis and secretion in neutrophils
both synaptotagmins I and II can interact with the syntaxin/synaptosomal-associated protein of 25 kDa (SNAP-25 (zeige SNAP25 Antikörper)) dimer
WNK1 (zeige WNK1 Antikörper) selectively binds to and phosphorylates synaptotagmin 2 (Syt2) within its calcium binding C2 domains. Endogenous WNK1 (zeige WNK1 Antikörper) and Syt2 coimmunoprecipitate and colocalize on a subset of secretory granules in INS-1 (zeige FOXM1 Antikörper) cells.
A recombinant fragment from the luminal domain of the human receptor protein syt (zeige SS18 Antikörper) II can bind specifically to botulinum neurotoxin B and its Hc domain.
Mutation of overexpressed Syt2 transgene leaves intrinsic calcium sensitivity of vesicles intact while it destabilizes the readily releasable pool of vesicles and loosens the tight coupling between calcium influx and release.
we identify Syt2 as a functionally important Ca(2 (zeige CA2 Antikörper)+) sensor at fast-releasing inhibitory synapses, and show that Syt1 (zeige SYT1 Antikörper) and Syt2 can redundantly control transmitter release at specific brain synapses
demonstrates a developmental Syt1 (zeige SYT1 Antikörper)-Syt2 isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.
the combined inactivation of all 3 E-Syt (zeige SS18 Antikörper) genes has no effect on mouse viability or fertility.
The 2.3-A structure of a ternary complex of botulinum neurotoxin type B (zeige BoNT/B Antikörper) bound to both its protein receptor synaptotagmin II and its ganglioside receptor GD1a, is reported.
Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis
Syt2 make it an excellent marker for analyzing the development and plasticity of perisomatic inhibitory innervations onto both excitatory and inhibitory neurons in the visual cortex.
Syt2 increases the dynamic range of synapses by driving release with a high Ca(2 (zeige CA2 Antikörper))+ cooperativity, as well as by suppressing a remaining, near-linear Ca(2 (zeige CA2 Antikörper))+ sensor.
Transient expression of Syt2 is no longer detected in cochlear inner hair cells (IHCs) after the onset of hearing, indicating that the most common calcium-sensors in central nervous system synapses are not involved in mature IHC ribbon synapse.
SYT2 was a negative regulator of chemotaxis
The readily releasable pool was rescued by Syt2 overexpression. The kinetics of fusion was slightly slower than in cells expressing Syt1. Syt2 has a lower Ca2+ affinity for phospholipid binding than Syt1 because of a difference in the C2A domain.
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994
, synaptotagmin 2