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Human SNCA ELISA Kit für Sandwich ELISA - ABIN1882403
Maia, Kaeser, Reichwald, Hruscha, Martus, Staufenbiel, Jucker: Changes in amyloid-? and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein. in Science translational medicine 2013
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Human SNCA ELISA Kit für Sandwich ELISA - ABIN414578
Alvarez-Erviti, Seow, Schapira, Gardiner, Sargent, Wood, Cooper: Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. in Neurobiology of disease 2011
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Mouse (Murine) SNCA ELISA Kit für Sandwich ELISA - ABIN415770
Fanara, Wong, Husted, Liu, Liu, Kohlstaedt, Riiff, Protasio, Boban, Killion, Killian, Epling, Sinclair, Peterson, Price, Cabin, Nussbaum, Brühmann, Brandt, Christine, Aminoff, Hellerstein: Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. in The Journal of clinical investigation 2012
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Human SNCA ELISA Kit für Sandwich ELISA - ABIN1059104
Johnson, Drugan, Miller, Evans: 38 in 1991
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg) during embryogenesis
These new mouse lines are invaluable for fast identification of cells with inactivation of Snca by Cre-recombination and represent useful tools for in vivo studies of alpha-synuclein function and dysfunction.
Results obtained with immuno-spin trapping and immunoprecipitation experiments confirmed formation of alpha-synuclein radicals in dopaminergic neurons of maneb and paraquat exposed mice.
Study showed that intracerebral injection of synthetic alpha-synuclein fibrils into adult wild-type marmoset brains (caudate nucleus and/or putamen) resulted in spreading of abundant alpha-synuclein pathologies, which were positive for various antibodies to alpha-synuclein, including phospho Ser129-specific antibody, anti-ubiquitin and anti-p62 antibodies, at three months after injection.
C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 (zeige MMRN1 ELISA Kits) genes, have an altered bone phenotype.
The findings of this study indicated a functional role of alpha-synuclein in early experimental autoimmune encephalomyelitis by increasing Th1 (zeige HAND1 ELISA Kits) cell-mediated immune response.
These data show that neurodegenerative processes associated with lysosomal dysfunction may be presynaptically initiated by a concomitant reduction in alpha-synuclein and CSPalpha levels at nerve terminals.
Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.
LRRK2 (zeige LRRK2 ELISA Kits) negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 (zeige LRRK2 ELISA Kits) in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.
sideroflexin 3 (SFXN3 (zeige SFXN3 ELISA Kits)) was found to be a mitochondrial protein (zeige COX6B2 ELISA Kits) localized to the inner mitochondrial membrane.
The ability of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions may be of importance when alpha-synuclein undergoes the misfolding and aggregation
Asymptomatic SNCA carriers do not manifest clear premotor symptoms, but symptomatic carriers often report that olfactory dysfunction and rapid eye movement sleep behavior disorder precede motor symptoms.
Several promising agents targeting PD-1 (zeige PDCD1 ELISA Kits)/PD-L1 (zeige CD274 ELISA Kits) are in clinical development. At present, there are limited datasets regarding their toxicity profiles, but available reports point to similar issues as those seen with nivolumab and pembrolizumab
Understanding immune escape from PD-L1 (zeige CD274 ELISA Kits)/PD-1 (zeige PDCD1 ELISA Kits)-targeted therapy will be important to the development of rational immune-combination therapy and predictive diagnostics and to the identification of novel immune targets.
In oncology, the two main classes of Checkpoint inhibitors (CPI), which are the most advanced in clinical development are the anti-CTLA-4 (zeige CTLA4 ELISA Kits) and anti-PD-1 (zeige PDCD1 ELISA Kits)/PD-L1 (zeige CD274 ELISA Kits) antibodies (Abs). Three of these Abs have been approved by the FDA (zeige FDA ELISA Kits) for clinical use.CPI can have efficacy across several types of cancer.
Phosphorylated alpha-synuclein is present at synapses exclusively in dementia with Lewy bodies cases (compared to Alzheimer's dementia cases and controls), where it can be identified in the form of Lewy bodies, Lewy neurites and small aggregates.
Long-term in vivo imaging of apical dendrites was performed in mice overexpressing wild-type human alpha-synuclein. Human alpha-synuclein overexpressing mice show decreased spine density and abnormalities in spine dynamics in an age-dependent manner.
Exosomes extracted from brains diagnosed with either Alzheimer's disease or Dementia with Lewy Bodies (DLB)contained aggregate-prone proteins. Furthermore, injection of brain-derived exosomes from DLB patients into the brains of wild type mice induced alpha-synuclein (alpha-syn) aggregation. Data imply exosomes may play a role in alpha-syn pathogenesis, possibly through the seeding of toxic forms of alpha-syn.
Study showed that alpha-synuclein perturbs endoplasmic reticulum-mitochondria associations and that this involves disruption to the VAPB (zeige VAPB ELISA Kits)-PTPIP51 (zeige FAM82A2 ELISA Kits) tethering proteins. Using a range of assays including immunoprecipitation, cellular glutathione S-transferase (zeige GSTa2 ELISA Kits) pull-down, proximity ligation and in vitro binding of recombinant proteins, study showed that alpha-synuclein is a direct binding partner for VAPB (zeige VAPB ELISA Kits).
Study found that interaction between alphaS and proaggregant nuclear factor(s) is associated with disruption of nuclear envelope integrity. Knocking down a key nuclear envelop constituent protein, lamin B1 (zeige LMNB1 ELISA Kits), enhances alphaS aggregation. Moreover, in vitro and in vivo experimental models demonstrate that aggregates released upon cell breakdown can be taken up by surrounding cells.
Study defines the alpha-synuclein-induced myelination deficit as a novel and crucial pathomechanism in multiple system atrophy. Importantly, the reversible nature of this oligodendrocytic dysfunction opens a novel avenue for an intervention in multiple system atrophy.
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (zeige TNFAIP1 ELISA Kits) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein