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In ORX-KO mice, the ultradian episodic changes in locomotor activity, EEG arousal indices and body temperature were significantly attenuated, but the ultradian patterning was preserved. Findings suggest that the ultradian pattern is common across species and that orexin contributes to driving ultradian episodic changes, however, this neuropeptide is not essential for ultradian pattern generation.
OXA and OX1R (zeige HCRTR1 Antikörper) are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.
Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R (zeige HCRTR1 Antikörper) signaling cascade due to decreased OX1R (zeige HCRTR1 Antikörper) expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.
Binding of OXA to OX1R (zeige HCRTR1 Antikörper) is important for the development of the testis.
Results suggest that orexin A bidirectionally modulates hippocampal CA1 (zeige CA1 Antikörper) synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C (zeige PLC Antikörper) and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations
DYN (zeige PDYN Antikörper)-A(2-17) interacts with orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.
Awake dynamics and brain-wide direct inputs of hypothalamic MCH (zeige PMCH Antikörper) and orexin/hypocretin networks have been discovered.
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency
observation that inhibition of the Orexin-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin circuits participate in the consumption of salient reinforcers regardless of calories.
Results suggest that exercise produces antidepressant effects via suppression of Hcrt/Orx and melanin-concentrating hormone (zeige PMCH Antikörper) neural systems in the basolateral amygdala
Orexin A levels correlated with age in females and were significantly elevated in PWS even after these effects were controlled. These findings support the hypothesis that dysregulation of orexin signaling may contribute to behavioral problems and hyperphagia in PWS.
Orexin levels do not play a role in the control of nocturnal blood pressure dipping in patients with narcolepsy type 1.
No association was observed between rs9902709 in HCRT and OSAHS (obstructive sleep apnea) risk in Chinese Han population.
findings show that in few patients with narcolepsy with cataplexy, symptoms and CSF (zeige CSF2 Antikörper) hypocretin-1 and histamine levels can change over time
actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1; very low hypocretin levels associate with more wake intruding into sleep
There was also a negative correlation between Epworth sleepiness scale scores and orexin levels in Prader-Willi syndrome patients. Decreased cerebrospinal fluid orexin levels in Prader-Willi syndrome may play an important role in severity of obesity and excessive daytime sleepiness.
orexin system may be involved even in the earliest stages of AD, resulting in prolonged sleep latency, reduced sleep efficiency, and REM (zeige REM1 Antikörper) sleep impairment.
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the gene for hypocretin.
Data indicate a positive correlation of nesfatin-1 (zeige NUCB2 Antikörper) and a negative correlation of orexin-A with body mass index.
The aim of the study was to determine by immunochemistry the expression of leptin (zeige LEP Antikörper), orexin A and orphanin FQ (zeige PNOC Antikörper) in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
first evidence for the expression of oxA and ox1R (zeige HCRTR1 Antikörper) in the vestibular glands of mammalian genital tract
The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs.
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
Hypocretin (orexin) neuropeptide
, orexin A
, orexin B