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Prdm3 (zeige MECOM ELISA Kits) and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.
Animals with the homozygote PRDM16 genotype had lower body weight and average daily gain than those with the other genotypes.
The genetic variation within PRDM16 gene in 1031 Chinese indigenous bovine, was analyzed.
Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa (zeige FLVCR1 ELISA Kits) cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer.
A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients
High PRDM16 expression is associated with astrocytoma.
Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia (zeige BCL11A ELISA Kits).
Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML (zeige RUNX1 ELISA Kits) and is associated with adverse outcome
PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis.
EVI1 (zeige MECOM ELISA Kits) and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia (zeige BCL11A ELISA Kits)
Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 (zeige PRDM6 ELISA Kits) locus) were associated with QRS (zeige QARS ELISA Kits) duration; and rs17026156 (SLC8A1 (zeige SLC8A1 ELISA Kits) locus) correlated with PR interval.
Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass.
MED1 (zeige MED1 ELISA Kits) is required for optimal PRDM16-induced Ucp1 (zeige UCP1 ELISA Kits) expression
Prdm16 is required for adult neural stem cell maintenance and neurogenesis as well as the formation of ependymal cells
A single subtype of ganglion cell appears to be uniquely marked by Prdm16 expression. While the precise identity of these ganglion cells is unclear, they most resemble the G9 subtype described by Volgyi and colleagues in 2009.
Gelidium elegans stimulates the expression of PRDM16 and UCP-1 (zeige UCP1 ELISA Kits) Protein in brown adipose tissue and suppresses hyperglycemia in high-fat diet mice.
Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta (zeige CEBPB ELISA Kits)) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige (zeige LYST ELISA Kits) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (zeige SLC39A13 ELISA Kits)
Prdm16 plays an important role in dynamic cellular redox changes in developing neocortex during neural differentiation.
Together, these data indicate that PRDM16 diminishes responsiveness to type I interferon (zeige IFNA ELISA Kits) in adipose cells to promote thermogenic and mitochondrial function.
the cellular levels of alpha-ketoglutarate (alphaKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter.
We further show that Cdkn1c (zeige CDKN1C ELISA Kits) is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C (zeige CDKN1C ELISA Kits) and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT (zeige SLC10A2 ELISA Kits).
PRDM16-induced C2C12 transdifferentiation is associated with alterations in CpG methylation of myogenic factors, and PR domain affects both myogenesis and adipogenesis with modified histone methylation marks on MyoD (zeige MYOD1 ELISA Kits) and PPARgamma (zeige PPARG ELISA Kits) promoters
PRDM16 deficiency in BAT (zeige BAAT ELISA Kits) reduces MED1 (zeige MBD4 ELISA Kits) binding at PRDM16 target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes
The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
PR domain containing 16
, PR domain zinc finger protein 16-like
, MDS1/EVI1-like gene 1
, PR domain zinc finger protein 16
, transcription factor MEL1
, PR domain-containing protein 16
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