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both bone morphogenetic protein 2 (BMP2 (zeige BMP2 Proteine)) and BMP6 (zeige BMP6 Proteine) are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3) and ALK2 (zeige ACRV1 Proteine), play crucial and distinct roles in this process.
BMPR1A and the ubiquitous isoform of BMPR1B differed in mode of translocation into the endoplasmic reticulum; and (ii) BMPR1A was N-glycosylated while BMPR1B was not, resulting in greater efficiency of processing and plasma membrane expression of BMPR1A.
Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG (zeige ENG Proteine), two in BMPR1A, one in PTEN, and one in SMAD4 (zeige SMAD4 Proteine). Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.
The present study suggests that HNF-4alpha has a suppressive effect on hepcidin expression by inactivating the BMP pathway, specifically via BMPR1A, in HepG2 cells.
In solid ameloblastoma, positive correlations were observed between the stromal and parenchymal expression of BMP-2 (zeige BMP2 Proteine) and between the stromal expression of BMP-2 (zeige BMP2 Proteine) and BMP-4 (zeige BMP4 Proteine), as well as between the stromal expression of BMPR-II (zeige BMPR2 Proteine) and BMP-4 (zeige BMP4 Proteine) and the stromal and parenchymal expression of BMPR-II (zeige BMPR2 Proteine).
Data show that protein kinase (zeige CDK7 Proteine) LKB1 (zeige STK11 Proteine) physically interacts with BMP type I receptors and requires Smad7 (zeige SMAD7 Proteine) protein to promote downregulation of the receptor.
BMPR1A(+) ASCs show an enhanced ability for adipogenesis in vitro, as shown by gene expression and histological staining.
Duplication of 10q22.3-q23.3 encompassing BMPR1A gene is associated with congenital heart disease, microcephaly, and mild intellectual disability
Authors analyzed human databases from TCGA and survival data from microarrays to confirm BMPR1a tumor promoting functions, and found that high BMPR1a gene expression correlates with decreased survival regardless of molecular breast cancer subtype.
About half of BMPR1A-related polyps displayed loss of heterozygosity, predominantly in the epithelial compartment, compatible with BMPR1A acting as a tumour suppressor gene.
These studies emphasize the pivotal role of BMPR1A in the determination of bone quality and mechanical integrity under physiological conditions, with different impact on femoral cortical and trabecular compartments.
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 Proteine) and SOST (zeige SOST Proteine), leading to osteoclast inhibition and Wnt (zeige WNT2 Proteine) activation together.
Data indicate the regulation of energy balance in BMPR1A-mediated appetite regulation in POMC (zeige POMC Proteine) neurons.
findings suggest that GJA1 may be one of the downstream targets of BMPR1A signaling in osteoclasts that mediates osteoclast-osteoblast communication during bone remodeling.
deletion of BMPR1a in oncogenic astrocytes resulted in decreased proliferation, decreased invasion, decreased migration, and increased expression of stemness markers
different levels of expression and subsequent activation of Smad (zeige SMAD1 Proteine) signaling differentially contribute each BMP type I receptor to BMP-Smad (zeige SMAD1 Proteine) signaling and craniofacial development.
BMP signaling mediated by coordination of ALK2/ACVR1 (zeige ACRV1 Proteine), ALK3/BMPR1A, and BMPR2 (zeige BMPR2 Proteine) is an essential proangiogenic cue for retinal vessels.
Gonadotrope-specific Bmpr1a knockout animals developed normally and had reproductive organ weights comparable with those of controls. Knockouts were fertile, with normal serum gonadotropins and pituitary gonadotropin subunit mRNA expression. Cre-mediated recombination of the floxed Bmpr1a allele was efficient and specific, as indicated by PCR analysis of diverse tissues and isolated gonadotrope cells.
CK2.1 peptide drives chondrogenesis and cartilage formation without induction of chondrocyte hypertrophy by releasing CK2 (zeige CSNK2A1 Proteine) from distinct sites at BMPRIa
These results suggest that Pax8 (zeige PAX8 Proteine) maybe the downstream molecule of ALK3, it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development.
Report temporal regulation of BMPR1a mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
ALK3 and ALK6 (zeige BMPR1B Proteine) both contribute to the gene regulatory network that regulates dorso-ventral patterning.
Data show that USP15 (zeige USP15 Proteine) enhances BMP-induced phosphorylation of SMAD1 (zeige SMAD1 Proteine) by interacting with and deubiquitylating ALK3.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
, BMP type-1A receptor
, activin A receptor, type II-like kinase 3
, activin receptor-like kinase 3
, bone morphogenetic protein receptor type-1A
, serine/threonine-protein kinase receptor R5
, BMP-2/BMP-4 receptor
, bone morphogenetic protein 4 receptor
, bone morphogenetic protein receptor, type 1A
, BMP receptor 1
, bone morphogenic protein receptor 1
, protein kinase
, bone morphogenetic protein receptor IA
, bone morphogenetic protein receptor, type IA
, bone morphogenetic protein receptor type-1A-like
, BMP receptor
, bone morphogenetic protein receptor type IA