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anti-Human NIPBL Antikörper:
anti-Mouse (Murine) NIPBL Antikörper:
anti-Rat (Rattus) NIPBL Antikörper:
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Mouse (Murine) Polyclonal NIPBL Primary Antibody für ELISA, IHC - ABIN4339765
Liu, Zhang, Bando, Itoh, Deardorff, Clark, Kaur, Tandy, Kondoh, Rappaport, Spinner, Vega, Jackson, Shirahige, Krantz: Transcriptional dysregulation in NIPBL and cohesin mutant human cells. in PLoS biology 2009
Human Polyclonal NIPBL Primary Antibody für ICC, IF - ABIN4339767
Xu, Ying, Shan, Feng, Zhang, Gao, Xu, Yao, Zhu, Mao: Enhanced expression of cohesin loading factor NIPBL confers poor prognosis and chemotherapy resistance in non-small cell lung cancer. in Journal of translational medicine 2015
Nipbl and mediator cooperatively regulate gene expression to control limb development.
The present s (zeige WNT2 Antikörper)tudy focuses on th (zeige CCND1 Antikörper)e role of the zebrafish nipblb paralog during neural development.
Nipbl-deficient embryos showed changes in the expression of genes involved in the specification of endoderm, which gives rise to gut (zeige GUSB Antikörper) and provides a substrate for cardiac precursor migration, as well as genes that regulate left-right asymmetry
NIPBL has evolved a sophisticated response to damaged DNA that is influenced by the form of damage, suggesting a highly dynamic role for NIPBL in maintaining genomic stability.
Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1 (zeige WWC1 Antikörper)), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3 (zeige CELSR3 Antikörper)), NIPBL (Nipped (zeige RPL38 Antikörper)-B-like), and FN1 (fibronectin 1 (zeige FN1 Antikörper)).
37 novel nipped-B-like protein (NIPBL) mutations were identified in Cornelia de Lange syndrome patients, including 34 in leukocytes and 3 in buccal cells only.
Pathological variant specific of the isoform A of NIPBL was identified in two patients with Cornelia de Lange Syndrome.
Subsequent quantitative PCR analysis demonstrated a 30% decrease of the total NIPBL mRNA levels associated with the frameshift transcript
NIPBL gene mutation is associated with Thrombocytopenia in Cornelia de Lange syndrome.
This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL and HDAC8 (zeige HDAC8 Antikörper) mutations and PKR (zeige PKLR Antikörper) activation.
NIPBL expression conferred poor prognosis and resistance to chemotherapy in non-small cell lung cancer
Scc2 normally promotes a gene expression program that supports translational fidelity. . translational dysfunction may contribute to the human disorder Cornelia de Lange syndrome, which is caused by mutations in NIPBL, the human ortholog of SCC2.
There was an increased frequncy of NIPBL mutations in a cohort of prenatal ultrasound detected phenotypes of Cornelia de Lange syndrome.
Depletion of Zfp609 or Nipbl from cortical neural progenitors in vivo is detrimental to neuronal migration. Zfp609 and Nipbl overlap at genomic binding sites independently of cohesin and regulate genes that control cortical neuron migration.
Nipbl transgenic mice display large atrial septal defects.
This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL and HDAC8 (zeige HDAC8 Antikörper) mutations and PKR (zeige EIF2AK2 Antikörper) activation.
expression analysis of Smc1a (zeige SMC1A Antikörper) and Nipbl in developing mouse embryos reveals a specific pattern in the hindbrain
Nipbl+/- mutants are growth-retarded and exhibit various skeletal and craniofacial malformations.
In spermatocytes, Nipbl/Mau2 (zeige KIAA0892 Antikörper) then relocalises to chromocenters, whereas in oocytes it remains bound to chromosomal axes throughout prophase to dictyate arrest.
Reduction of Nipbl is associated with Cornelia de Lange Syndrome.
Mice heterozygous for a gene-trap mutation in Nipbl were produced and exhibited defects characteristic of Cornelia de Lange Syndrome.
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene.
, sister chromatid cohesion establishment factor 2
, nipped-B homolog
, Nipped-B homolog (Drosophila)
, nipped-B like a
, nipped-B-like protein B
, nipped-B-like protein-like
, SCC2 homolog
, nipped-B-like protein
, sister chromatid cohesion 2 homolog
, delangin homolog