anti-Human Norrie Disease (Pseudoglioma) Antikörper für Enzyme Immunoassay

Recommended Norrie Disease (Pseudoglioma) Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Norrie Disease (Pseudoglioma) (NDP) Antikörper
  • EVR2
  • FEVR
  • ND
  • evr2
  • fevr
  • xnorrin
  • Ndph
  • RGD1563968
  • Norrie disease (pseudoglioma)
  • Norrie disease (pseudoglioma) (human)
  • NDP
  • ndp
  • Ndp
Epitop
N-Term
8
6
2
1
1
Reaktivität
Human
30
9
7
1
1
1
1
1
Wirt
Kaninchen
27
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
23
12
10
10
4
4
3
2
2
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN5555063
$ 375.38
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN5568207 EIA RIA Biotin Rabbit AA 25-133 Anmelden zum Anzeigen Polyclonal
1 ABIN5568205 EIA RIA Rabbit AA 25-133 Anmelden zum Anzeigen Polyclonal

General

Antigen Norrie Disease (Pseudoglioma) (NDP) Antikörper
Epitop N-Term
(8), (6), (2), (1), (1)
Reaktivität Human
(30), (9), (7), (1), (1), (1), (1), (1)
Wirt Kaninchen
(27), (4)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(23), (12), (10), (10), (4), (4), (3), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Spezifität This antibody detects NDP.
Kreuzreaktivität (Details) Species reactivity (tested):Human
Reinigung Peptide affinity chromatography
Immunogen Norrin antibody was raised against an 18 amino acid peptide from near the amino terminus of human Norrin.
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung NDP (NDP Antibody Abstract)
Hintergrund Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes, mental disturbances and deafness. The gene responsible for this disease was initially identified through positional cloning. Norrin, the gene product, encodes a small secreted, cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/b-catenin signal pathway despite having sequence homology with the Wnt family of proteins. Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina, transgenic ectopic expression of Norrin restores normal retinal vasculature. Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/b-catenin pathway and regulating the phosphorylation of LRP-1, a cell surface receptor for tPA and uPA, suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1.Synonyms: EVR2, Norrie disease protein, Norrin
Gen-ID 4693
NCBI Accession NP_000257
UniProt Q00604
Forschungsgebiet Stem Cells, Wnt, Wnt Signaling
Pathways Sensory Perception of Sound

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikationshinweise ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Buffer PBS containing 0.02 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.