anti-Human Cholinergic Receptor, Nicotinic, alpha 10 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended Cholinergic Receptor, Nicotinic, alpha 10 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10) Antikörper
  • si:dkey-24p1.3
  • ALPHA 10 nAChR
  • cholinergic receptor, nicotinic, alpha 10
  • cholinergic receptor, nicotinic, alpha 10 (neuronal)
  • cholinergic receptor, nicotinic, alpha polypeptide 10
  • chrna10
  • CHRNA10
  • Chrna10
Epitop
AA 186-214, Middle Region
14
10
7
5
5
3
3
2
1
Reaktivität
Human
60
28
27
3
1
1
1
Wirt
Kaninchen
59
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
44
26
18
16
13
9
4
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN951514
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN656120 IHC (p) WB Rabbit Ig AA 179-206, Center Anmelden zum Anzeigen Polyclonal 1
1 ABIN5535885 IHC (p) WB Rabbit Ig Fraction AA 179-206 Anmelden zum Anzeigen Polyclonal
1 ABIN2879350 IHC (p) ELISA WB Rabbit IgG AA 394-443 Anmelden zum Anzeigen Polyclonal
1 ABIN2962293 IHC (p) ELISA WB Rabbit IgG AA 394-443 Anmelden zum Anzeigen Polyclonal
1 ABIN2962294 IHC (p) WB Rabbit AA 179-206 Anmelden zum Anzeigen Polyclonal
1 ABIN1413116 IHC (p) WB HRP Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN1395223 IHC (p) WB Biotin Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2739948 IHC (p) WB Rabbit AA 179-206 Anmelden zum Anzeigen Polyclonal
1 ABIN1387662 FACS IF (p) IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal

General

Antigen Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10) Antikörper
Epitop AA 186-214, Middle Region
(14), (10), (7), (5), (5), (3), (3), (2), (1)
Reaktivität Human
(60), (28), (27), (3), (1), (1), (1)
Wirt Kaninchen
(59), (2)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(44), (26), (18), (16), (13), (9), (4), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Spezifität This antibody reacts to CHRNA10.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Affinity chromatography on Protein A
Immunogen KLH conjugated synthetic peptide between 186-214 amino acids from the Central region of human CHRNA10
Isotyp Ig

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung CHRNA10 (CHRNA10 Antibody Abstract)
Hintergrund CHRNA10 is an ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.Synonyms: NACHR alpha-10, NACHRA10, Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-10
Molekulargewicht 49705 Da
Gen-ID 57053
NCBI Accession NP_065135
Forschungsgebiet Neurology
Pathways Sensory Perception of Sound, Synaptic Membrane

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Saccone, Schwantes-An, Wang, Grucza, Breslau, Hatsukami, Johnson, Rice, Goate, Bierut: "Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans." in: Genes, brain, and behavior, Vol. 9, Issue 7, pp. 741-50, 2010

Saccone, Saccone, Hinrichs, Stitzel, Duan, Pergadia, Agrawal, Breslau, Grucza, Hatsukami, Johnson, Madden, Swan, Wang, Goate, Rice, Bierut: "Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 150B, Issue 4, pp. 453-66, 2009

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10) (AA 186-214), (Middle Region) antibody (ABIN951514) CHRNA10 Antibody (Center) immunohistochemistry analysis in formalin fixed and p...
Western Blotting (WB) image for anti-Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10) (AA 186-214), (Middle Region) antibody (ABIN951514) CHRNA10 Antibody (Center) western blot analysis in NCI-H292,MDA-MB453,ZR-75-1 c...