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SHC1 Proteine (SHC1)

Bezeichnung:
SHC (Src Homology 2 Domain Containing) Transforming Protein 1 Proteine (SHC1)
Auf www.antikoerper-online.de finden Sie aktuell 11 SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SHC1 Antikörper (236) und SHC1 Kits (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 271 SHC1 Produkte verfügbar.
Synonyme:
p66, p66shc, Shc, SHC1, ShcA, si:dkey-246i14.4, wu:fc10h03
alle Proteine anzeigen Gen GeneID UniProt
SHC1 6464 P29353
SHC1 85385 Q5M824
SHC1 20416 P98083

Weitere Synonyme anzeigen

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Am meisten referenzierte SHC1 Proteine

  1. Human SHC1 Protein expressed in Escherichia coli (E. coli) - ABIN667498 : Debnath: p66(Shc) and Ras: controlling anoikis from the inside-out. in Oncogene 2010 (PubMed)
    Zeige alle 2 Referenzen für ABIN667498

Weitere Proteine zu SHC1 Interaktionspartnern

Human SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (zeige POLD3 Proteine)CA (p66) activation invol (zeige SIGLEC1 Proteine)ving Ser(139) and a motif surroun (zeige SIGLEC1 Proteine)ding Ser(213).

  2. Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (zeige POLD3 Proteine) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.

  3. regulates the alternative splicing of XAF1 (zeige XAF1 Proteine) in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death

  4. The silence of p66(Shc) in HCT8 cells reduced the proliferation and accelerated the apoptosis, in addition, the expression of pro-apoptotic proteins caspase-3 (zeige CASP3 Proteine), caspase-9 (zeige CASP9 Proteine), Bax (zeige BAX Proteine) was enhanced and the expression of anti-apoptotic protein Bcl-2 (zeige BCL2 Proteine) was declined.

  5. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (zeige INS Proteine) resistance.

  6. Data suggest SHC1 (SH2 domain protein C1) expression down-regulates epithelial-mesenchymal transition by repressing TGFB (zeige TGFB1 Proteine)-induced SMAD2 (zeige SMAD2 Proteine)/3 activation through differential partitioning of receptors at cell surface of mammocytes/keratinocytes.

  7. p66shc expression in coronary heart disease patients was significantly higher compared with the control group

  8. Finally, a crystal structure of EGFR (zeige EGFR Proteine) in complex with a primed Shc1 peptide reveals the structural basis for EGFR (zeige EGFR Proteine) substrate specificity.

  9. p53 (zeige TP53 Proteine)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity

  10. Data show that ouabain-induced glioblastoma cells apoptosis and increased reactive oxygen species (ROS (zeige ROS1 Proteine)) generation in extracellular signal-related kinases ERK1/2-Shc signaling adaptor protein p66SHC-dependent pathway.

Zebrafish SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.

Xenopus laevis SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. ShcA is required for Wnt-5a (zeige WNT5A Proteine)/Ror2 (zeige ROR2 Proteine) mediated upregulation of xPAPC (zeige PCDH8 Proteine), which demonstrates the functional relevance of this interaction.

Cow (Bovine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (zeige CAT Proteine).

  2. p66shc, but not p53 (zeige TP53 Proteine), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.

  3. p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos

  4. These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.

Mouse (Murine) SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Interaktionspartner

  1. Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (zeige MLXIP Proteine)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (zeige SIRT1 Proteine).

  2. p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.

  3. Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (zeige POLD3 Proteine) activation involving Ser (zeige SIGLEC1 Proteine)(139) and a motif surrounding Ser (zeige SIGLEC1 Proteine)(213).

  4. JNK1 (zeige MAPK8 Proteine)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.

  5. Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (zeige HADHB Proteine) ACAA2 (zeige ACAA2 Proteine), to which p46Shc binds directly and with a strong affinity.

  6. In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (zeige INS Proteine) resistance.

  7. p53 (zeige TP53 Proteine)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity

  8. Silencing of p66(Shc) restored insulin (zeige INS Proteine) response via IRS-1 (zeige IRS1 Proteine)/Akt (zeige AKT1 Proteine)/eNOS (zeige NOS3 Proteine) pathway. Its knockdown in endothelial cells from Ob/Ob mice lessened ROS (zeige ROS1 Proteine) production, FFA oxidation, and dysregulation of redox-sensitive pathways.

  9. These data identify multiple modes by which ShcA can fine-tune the development of early thymocytes, including a previously unappreciated ShcA-c-Abl axis that regulates thymocyte proliferation.

  10. PKCbeta2 inhibition protects mice from gut (zeige GUSB Proteine) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.

SHC1 Protein Überblick

Protein Überblick

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SHC1

  • SHC (Src homology 2 domain containing) transforming protein 1 (SHC1)
  • Shc1p (SHC1)
  • squalene--hopene cyclase (shc1)
  • SHC (Src homology 2 domain containing) transforming protein 1 (LOC100229782)
  • SHC (Src homology 2 domain containing) transforming protein 1 (Shc1)
  • SHC (Src homology 2 domain containing) transforming protein 1 (shc1)
  • src homology 2 domain-containing transforming protein C1 (Shc1)
  • p66 Protein
  • p66shc Protein
  • Shc Protein
  • SHC1 Protein
  • ShcA Protein
  • si:dkey-246i14.4 Protein
  • wu:fc10h03 Protein

Bezeichner auf Proteinebene für SHC1

SHC (Src homology 2 domain containing) transforming protein 1 , Shc1p , Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH , squalene--hopene cyclase , SH2 domain protein C1 , SHC-transforming protein 1 , src homology 2 domain-containing-transforming protein C1 , SHC-transforming protein 1-like , SHC (Src homology 2 domain-containing) transforming protein 1 , SHC-transforming protein 3 , SHC-transforming protein A , src homology 2 domain-containing transforming protein C1 , p60Shc , src homology collagen , adaptor protein SHC

GENE ID SPEZIES
457351 Pan troglodytes
856832 Saccharomyces cerevisiae S288c
4234272 Frankia alni ACN14a
4944146 Saccharopolyspora erythraea NRRL 2338
100016090 Monodelphis domestica
100063053 Equus caballus
100173225 Pongo abelii
100390337 Callithrix jacchus
100480856 Ailuropoda melanoleuca
100540048 Meleagris gallopavo
100606068 Nomascus leucogenys
100229782 Taeniopygia guttata
6464 Homo sapiens
85385 Rattus norvegicus
323818 Danio rerio
399198 Xenopus laevis
395934 Gallus gallus
490439 Canis lupus familiaris
507196 Bos taurus
20416 Mus musculus
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