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RYK and VANGL2 (zeige VANGL2 Proteine) proteins form a complex, whereas RYK also activated RhoA (zeige RHOA Proteine), a downstream effector of PCP (zeige PRCP Proteine) signaling.
Data suggest that full-length Ryk conveys Wnt5b (zeige WNT5B Proteine) signals in a directional manner during gastrulation.
our findings demonstrate that Ryk promotes stem cell-like and tumorigenic features to glioma cells its essential for the maintenance of glioblastoma stem cells
Wnt5A (zeige WNT5A Proteine)/Ryk signaling might provide novel therapeutic strategies to prevent capillary leakage in systemic inflammation and septic shock.
results corroborated previous findings of Ryk-mediated Wnt5a (zeige WNT5A Proteine) effect, and suggested a role for Ror2 (zeige ROR2 Proteine) in the Wnt5a (zeige WNT5A Proteine) machinery in glioblastoma
Early treatment with HGF (zeige HGF Proteine)/IgG complexes after myocardial ischaemia with reperfusion may rescue tissue through vasoprotection conferred by c-Met and RYK signalling
Ryk-intracellular domain pathway may impair FOXO (zeige FOXO3 Proteine) protective activity in mutant polyglutamine neurons, suggesting neurons unable to efficiently maintain function and resist disease from the earliest phases of the pathogenic process in Huntington disease (zeige HTT Proteine)
is a candidate wnt5a (zeige WNT5A Proteine) receptor.
The Ryk is important for the Wnt-5a (zeige WNT5A Proteine)-dependent induction of MMP-2 (zeige MMP2 Proteine) and invasive activity in glioma-derived cells and that Ryk might have a novel patho-physiological function in adult cancer invasion.
RYK interacts both physically and functionally with the E3 ubiquitin MIB1. MIB1 is sufficient to activate Wnt (zeige WNT2 Proteine)/CTNNB1 (zeige CTNNB1 Proteine) signaling and this activity depends on endogenous RYK.
RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.
reveal a novel function of Ryk signaling in controlling motor cortex remapping after spinal cord injury in adulthood.
Ryk deficiency in hematopoietic stem cells from fetal liver reduces their quiescence, leading to proliferation-induced apoptosis and decreased self-renewal.
Wnt5a (zeige WNT5A Proteine) regulates HSC (zeige FUT1 Proteine) quiescence and hematopoietic repopulation through the Ryk receptor and that this process is mediated by suppression of reactive oxygen species.
Ryk inhibits axonal growth in response to Wnt5a (zeige WNT5A Proteine).
Ryk is an important mediator of ventral midbrain dopaminergic neuron development.
Ryk regulates Wnt5a (zeige WNT5A Proteine) signaling and planar cell polarity by modulating the degradation of Vangl2 (zeige VANGL2 Proteine).
RYK and VANGL2 (zeige VANGL2 Proteine) proteins form a complex, whereas RYK also activated RhoA (zeige RHOA Proteine), a downstream effector of PCP (zeige BMP1 Proteine) signaling.
Results identify Ryk as a multi-functional receptor that is able to transduce extrinsic cues into progenitor cells, promote GABAergic neuron formation, and inhibit oligodendrogenesis during ventral embryonic brain development.
Mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt (zeige WNT2 Proteine) ligands.
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
RYK receptor-like tyrosine kinase
, tyrosine kinase RYK
, ryk receptor-like tyrosine kinase
, receptor-like tyrosine kinase
, tyrosine-protein kinase RYK
, tyrosine kinase-related protein
, tyrosine-protein kinase RYK-like
, JTK5A protein tyrosine kinase
, hydroxyaryl-protein kinase
, growth factor receptor
, kinase VIK
, met-related kinase