NFATC1 Proteine (NFATC1)

Bezeichnung:
Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 Proteine (NFATC1)
Auf www.antikoerper-online.de finden Sie aktuell 5 Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen NFATC1 Antikörper (153) und NFATC1 Kits (17) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 185 NFATC1 Produkte verfügbar.
Synonyme:
2210017P03Rik, AI449492, AV076380, NF-ATC, NF-ATc1, NFAT, NFAT2, NFATc, NFATC1, Nfatcb, NFATmac, si:ch211-198c22.2
alle Proteine anzeigen Gen GeneID UniProt
NFATC1 18018  
NFATC1 4772 O95644
Ratte NFATC1 NFATC1 100361818  

Weitere Synonyme anzeigen

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Weitere Proteine zu NFATC1 Interaktionspartnern

Mouse (Murine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Interaktionspartner

  1. Inhibition of calcineurin (zeige PPP3CA Proteine) activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (zeige CTSK Proteine) protein expression.

  2. astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (zeige PPP3CA Proteine) (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (zeige NFATC3 Proteine)

  3. In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.

  4. Immunoreceptor tyrosine-based inhibitory motif DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2 (zeige CA2 Proteine)+) axis.

  5. TNF (zeige TNF Proteine)/IL-6 (zeige IL6 Proteine) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12 (zeige TYROBP Proteine), and cell proliferation.

  6. PRIP (zeige NCOA6 Proteine) deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP (zeige NCOA6 Proteine) stimulates osteoclast differentiation through calcium-calcineurin (zeige PPP3CA Proteine)-NFATc1 signaling via regulating intracellular Ca(2 (zeige CA2 Proteine)+)

  7. Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 and Sp1 (zeige SP1 Proteine), reducing the level of free Sp1 (zeige SP1 Proteine) to inhibit microRNA miR (zeige MLXIP Proteine)-139-5p expression and promote osteoclastogenesis.

  8. In summary, gastrodin could prevent osteoclasts formation and bone resorption via blockage of NFATc1 activity, and stimulate osseointegration in vitro. Gastrodin could be developed as a potent phytochemical candidate to treat osteolytic diseases.

  9. this study shows that lipopolysaccharide priming of dendritic cells stabilizes their tolerogenicity through CD14 (zeige CD14 Proteine):NFATc signaling

  10. MK serves an indispensable role in the NFAT-regulated activation of CD4 (zeige CD4 Proteine)(+) T cells and Th1 (zeige HAND1 Proteine) cell differentiation.

Human Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Interaktionspartner

  1. there is an NFATc1/ABCA1 (zeige ABCA1 Proteine)-dependent mechanism in which local TNF (zeige TNF Proteine) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (zeige TNF Proteine), TNFR1 (zeige TNFRSF1A Proteine), or TNFR2 (zeige TNFRSF1B Proteine) serum levels

  2. NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (zeige FLVCR1 Proteine)) specimens and PCa (zeige FLVCR1 Proteine) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells

  3. DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.

  4. In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.

  5. NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.

  6. revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (zeige NFAT1 Proteine) in T cells, such as Raptor (zeige RPTOR Proteine), CHEK1 (zeige CHEK1 Proteine), CREB1 (zeige CREB1 Proteine), RUNX1 (zeige RUNX1 Proteine), SATB1 (zeige SATB1 Proteine), Ikaros (zeige IKZF1 Proteine), and Helios (zeige ZNFN1A2 Proteine).

  7. NFATc1 silencing regulates the cell cycle.

  8. Study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4 (zeige POU5F1 Proteine)/Sox2 (zeige SOX2 Proteine) signal via NFATc1.

  9. The enhanced osteoclast formation by TECK (zeige CCL25 Proteine) was mediated by NFATc1, but not by NF-kB signaling.

  10. NFATC1 promoteds growth of ovarian cancer cells up-regulating c-myc (zeige MYC Proteine) through activation of ERK1/2/p38/MAPK (zeige MAPK14 Proteine) signal pathway.

Cow (Bovine) Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1) Interaktionspartner

  1. In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.

  2. regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes

NFATC1 Protein Überblick

Protein Überblick

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Alternative names and synonyms associated with NFATC1

  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1)
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (nfatc1)
  • nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 (Nfatc1)
  • nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (Nfatc1)
  • 2210017P03Rik Protein
  • AI449492 Protein
  • AV076380 Protein
  • NF-ATC Protein
  • NF-ATc1 Protein
  • NFAT Protein
  • NFAT2 Protein
  • NFATc Protein
  • NFATC1 Protein
  • Nfatcb Protein
  • NFATmac Protein
  • si:ch211-198c22.2 Protein

Bezeichner auf Proteinebene für NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 , nuclear factor of activated T-cells, cytosolic component 1 , nuclear factor of activated T-cells calcineurin-dependent 1 , nuclear factor of activated T-cells, cytoplasmic 1 , nuclear factor of activated T-cells, cytoplasmic 1-like , NF-ATc1 , NFAT transcription complex cytosolic component , transcription factor NF-ATc , NFATc , transcription factor NFATmac

GENE ID SPEZIES
420815 Gallus gallus
444346 Xenopus laevis
455485 Pan troglodytes
568315 Danio rerio
698089 Macaca mulatta
780197 Xenopus (Silurana) tropicalis
100023153 Monodelphis domestica
100065378 Equus caballus
100436209 Pongo abelii
100470861 Ailuropoda melanoleuca
100545778 Meleagris gallopavo
100565300 Anolis carolinensis
18018 Mus musculus
4772 Homo sapiens
100361818 Rattus norvegicus
483925 Canis lupus familiaris
511224 Bos taurus
397318 Sus scrofa
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