FLT1 Proteine (FLT1)

Bezeichnung:
Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) Proteine (FLT1)
Auf www.antikoerper-online.de finden Sie aktuell 74 Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Proteine von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FLT1 Antikörper (504) und FLT1 Kits (67) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 666 FLT1 Produkte verfügbar.
Synonyme:
AI323757, FLT, FLT-1, FLT1, flt1b, sFlt1, VEGFR-1, VEGFR1
alle Proteine anzeigen Gen GeneID UniProt
FLT1 14254 P35969
FLT1 2321 P17948
FLT1 54251 P53767

Weitere Synonyme anzeigen

FLT1 Proteine (FLT1) nach Spezies

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Am meisten referenzierte FLT1 Proteine

  1. Human FLT1 Protein expressed in HEK-293 - ABIN2666538 : Ambati, Nozaki, Singh, Takeda, Jani, Suthar, Albuquerque, Richter, Sakurai, Newcomb, Kleinman, Caldwell, Lin, Ogura, Orecchia, Samuelson, Agnew, St Leger, Green, Mahasreshti, Curiel, Kwan, Marsh et al.: Corneal avascularity is due to soluble VEGF receptor-1. ... in Nature 2006 (PubMed)
    Zeige alle 7 Referenzen für 2666538

  2. Human FLT1 Protein expressed in HEK-293 Cells - ABIN2181915 : Shibuya, Yamaguchi, Yamane, Ikeda, Tojo, Matsushime, Sato: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. in Oncogene 1990 (PubMed)
    Zeige alle 5 Referenzen für 2181915

  3. Rat (Rattus) FLT1 Protein expressed in Human Cells - ABIN2009153 : Kendall, Thomas: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Zeige alle 2 Referenzen für 2009153

  4. Human FLT1 Protein expressed in Human Cells - ABIN2002149 : Starovasnik, Christinger, Wiesmann, Champe, de Vos, Skelton: Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. in Journal of molecular biology 1999 (PubMed)
    Zeige alle 2 Referenzen für 2002149

Weitere Proteine zu FLT1 Interaktionspartnern

Mouse (Murine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Interaktionspartner

  1. endothelial dysfunction due to high circulating sFLT1 may be the primary event leading to enhanced vasoconstrictor sensitivity that is characteristic of preeclampsia

  2. Flt1 has a role in blood vessel anastomosis during angiogenesis

  3. First-in-class selective PET tracers for imaging VEGFR-1 and VEGFR-2 (zeige KDR Proteine) were constructed and successfully validated in an orthotopic murine tumor model.

  4. these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in streptozotocin -induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis.

  5. These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B (zeige VEGFB Proteine) to VEGFR1.

  6. Flt1/VEGF-A (zeige VEGFA Proteine) signalling has stage-specific effects on vascular morphogenesis.

  7. IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor and its receptors

  8. the VEGFR-1 tyrosine kinase (zeige TYRO3 Proteine) signaling has an effect on angiogenesis.

  9. data suggest that sFlt-1 may have a therapeutic effect on AS, resulting from suppression of VEGF signaling-mediated recruitment of circulating monocytes/macrophages

  10. that Flt-1 plays a critical role in cardiac hypertrophy induced by pressure overload via the activation of AKT (zeige AKT1 Proteine)

Human Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Interaktionspartner

  1. Results indicate that chymotrypsin-like serine protease (zeige F2 Proteine) enhances soluble fms-like tyrosine kinase 1 production through protease-activated receptor-2 (zeige F2RL1 Proteine) in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.

  2. variants near FLT1 may modulate preeclampsia susceptibility

  3. Flt1 has a role in blood vessel anastomosis during angiogenesis

  4. variants rs35832528 (E982A; P=2.49E-4; odds ratio=0.387) and rs141440705 (R54S; P=0.003; odds ratio=0.442) in Fms related tyrosine kinase 1 significantly associated with maternal protective genetic variants in Preeclampsia in the Finnish Population.

  5. Serum and urinary sFlt-1 and sFlt-1/PLGF (zeige PGF Proteine) ratios in severe preeclampsia patients were significantly higher than those in the mild preeclampsia group, and measurements from mild preeclampsia patients were significantly higher than controls

  6. FLT-1 rs7324510 C/A variant may be a new genetic risk factor for severity of rheumatoid arthritis. Examined factor highly predispose to more severe disease activity as well as higher sFLT-1 levels in rheumatoid arthritis.

  7. Molecular dynamics simulations of VEGFR-1 Wt and (p.Cys1110Ser) variant revealed exposure of the activation domain increasing the probability of phosphorylation events: a condition frequently reported in cancers.

  8. The normalized methylation values for the VEGFR1, VEGFR2 (zeige KDR Proteine) and VEGFR3 (zeige FLT4 Proteine) promoters tended to be higher in the tumour cell lines than in normal tonsil samples, whereas amounts of VEGFR1, VEGFR2 (zeige KDR Proteine) and VEGFR3 (zeige FLT4 Proteine) messenger RNA were significantly higher

  9. Both the TNF-alpha (zeige TNF Proteine)/IL-10 (zeige IL10 Proteine) and sFlt-1/PlGF (zeige PGF Proteine) ratios were higher in placental homogenate of early-onset Preeclampsia (PE) than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha (zeige TNF Proteine)/IL-10 (zeige IL10 Proteine) and PlGF (zeige PGF Proteine)/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE

  10. this study shows that Fli-1 (zeige FLI1 Proteine) plays a major role in the regulation of granulocyte colony stimulating factor (zeige CSF3 Proteine)

Cow (Bovine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Interaktionspartner

  1. There is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1.

  2. These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.

  3. VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.

  4. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1

  5. VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)

  6. Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  7. inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.

  8. TGF-beta1 (zeige TGFB1 Proteine) induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen(VEGFR-1)

  9. the activation of VEGFR-1 and VEGFR-2 (zeige KDR Proteine) heterodimer (VEGFR-1/R-2) is essential for PGI(2 (zeige PTGIR Proteine)) synthesis mediated by VEGF-A (zeige VEGFA Proteine)(165) and VEGF-A (zeige VEGFA Proteine)(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 (zeige KDR Proteine) homodimers with corresponding agonists

  10. PEDF (zeige SERPINF1 Proteine) and VEGFR-1 have roles in the negative regulation of angiogenesis

Pig (Porcine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Interaktionspartner

  1. we analyzed the expression and cellular distribution of Flt-1(VEGFR-1) and Flk-1 (KDR/VEGFR-2 (zeige KDR Proteine))in newborn piglet brain

  2. data shows that members of the VEGF (zeige VEGFA Proteine)-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  3. The VEGFR1 was stably expressed during the whole lifespan of mesonephric glomeruli, and VEGFR1 is important for the maintenance of endothelial fenestrations.

  4. increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig.

  5. EGFR (zeige EGFR Proteine), VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  6. VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.

  7. VEGF (zeige VEGFA Proteine)/Flk-1 (zeige KDR Proteine)/Flt-1 system is activated during myocardial ischemia reperfusion injury.

  8. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2 (zeige MMP2 Proteine), VEGFR-1, VEGFR-2 (zeige KDR Proteine), and TIMP-1 (zeige TIMP1 Proteine), which may contribute to the development of venous stenosis.

  9. in experimental intervertebral disc degeneration, VEGF receptors were expressed in the damaged disc and paradiscal tissues

Zebrafish Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Interaktionspartner

  1. Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt (zeige AKT1 Proteine) pathway.

  2. Elevated Notch (zeige NOTCH1 Proteine) signaling downstream of perturbed VEGF (zeige VEGFA Proteine) signaling contributes to aberrant flt-1(-/-) blood vessel formation.

  3. Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 (zeige LILRB2 Proteine) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 (zeige KDR Proteine) signaling.

FLT1 Protein Überblick

Protein Überblick

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Alternative names and synonyms associated with FLT1

  • fms-related tyrosine kinase 1 (FLT1)
  • vascular endothelial growth factor receptor 1 (CpipJ_CPIJ012087)
  • FMS-like tyrosine kinase 1 (Flt1)
  • FMS-related tyrosine kinase 1 (Flt1)
  • fms-related tyrosine kinase 1 (Flt1)
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1)
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (flt1)
  • vascular endothelial growth factor receptor-1 (FLT-1)
  • AI323757 Protein
  • FLT Protein
  • FLT-1 Protein
  • FLT1 Protein
  • flt1b Protein
  • sFlt1 Protein
  • VEGFR-1 Protein
  • VEGFR1 Protein

Bezeichner auf Proteinebene für FLT1

fms-related tyrosine kinase 1 , vascular endothelial growth factor receptor 1 , embryonic receptor kinase 2 , tyrosine-protein kinase receptor FLT , vascular endothelial growth factor receptor-1 , vascular permeability factor receptor , fms-like tyrosine kinase 1 , fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , tyrosine-protein kinase FRT , FLT-1 , FMS-like tyrosine kinase 1 , Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , VEGF-receptor , flt-receptor , vascular endothelial growth factor 1 , vascular endothelial growth factor/vascular permeability factor receptor , ascular endothelial growth factor/vascular permeability factor receptor , VEGFR-1 , flt-1 type VEGF receptor , receptor tyrosine kinase Flt1b , soluble fms-like tyrosine kinase 1

GENE ID SPEZIES
443088 Ovis aries
6044537 Culex quinquefasciatus
14254 Mus musculus
2321 Homo sapiens
54251 Rattus norvegicus
100732326 Cavia porcellus
503620 Bos taurus
403727 Canis lupus familiaris
374100 Gallus gallus
396763 Sus scrofa
544667 Danio rerio
443182 Ovis aries
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