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Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP (zeige FMR1 Proteine) interactor, is detected in fragile X (zeige FMR1 Proteine) syndrome.
blood samples of lateral sclerosis patients were found to have significantly different levels of expression of CyFIP2 and RbBP9 (zeige RBBP9 Proteine) compared to the levels of expression in control subjects.
Studies identify a novel proapoptotic gene target, CYFIP2, which is downregulated by IMP-1, and mediates the regulation of cell survival and K-Ras expression in colon cancer cells.
Protein complexes containing CYFIP (zeige CYFIP1 Proteine)/Sra (zeige SRA1 Proteine)/PIR121 coordinate Arf1 (zeige ARF1 Proteine) and Rac1 signalling during clathrin-AP-1 (zeige FOSB Proteine)-coated carrier biogenesis at the trans-golgi network.
The CYFIP2 promoter contains a p53 (zeige TP53 Proteine)-responsive element that confers p53 (zeige TP53 Proteine) binding as well as transcriptional activation of a heterologous reporter.
cyfip2 is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
Study identified cytoplasmic FMR1-Interacting Protein 2 (Cyfip2) as a major significant genetic factor underlying binge eating and provide a behavioral paradigm for future genome-wide association studies in populations with increased genetic complexity.
Study provides evidence for the role of Cyfip2 in fragile X (zeige FMR1 Proteine)-like behaviors and regulation of dendritic spines, and for the mGluR (zeige GRM8 Proteine)-induced regulation of Cyfip2 expression, which could provide new insight into the pathogenesis of the neurological fragile X (zeige FMR1 Proteine) syndrome phenotypes.
Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity).
cytoplasmic FMR1 interacting protein 2
, cytoplasmic FMR1-interacting protein 2
, p53 inducible protein
, p53-inducible protein 121